Nancy Wilson Schlei

Senior Scientist

Department:

Nancy Wilson SchleiMedicine

Contact Information:

  • (608) 263-3369

Curriculum Vitae:

Nancy Wilson Schlei's Curriculum Vitae

Aligned research focus:

Rhesus tetramer development, Kidney fibrogenesis and transplant models

Organ system/disease focus:

We have developed a panel of MHC class I tetramers for the rhesus macaque that spans the SIV genome as well as the most frequent alleles of interest. These are available to all SIV researchers.

My other focus is kidney fibrogenesis and the immunology and biochemistry of kidney transplantation.

Research description:

The most efficacious way to blunt the continued expansion of HIV/AIDS infection is development of an effective vaccine. We have developed reagents to support the development of T cell based vaccines. These reagents allow identification and sorting of T cells which have particular MHC class I/SIV peptide pairs as their targets. These reagents allow a rapid, comprehensive means to follow vaccine trials after vaccination as well as after challenge.

Selected references:

Giraldo-Vela JP, Bean AT, Rudersdorf R, Wallace LT, Loffredo JT, Erickson P, Wilson NA, Watkins DI. Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid. Immunogenetics. 2010 Oct;62(10):701-7. Epub 2010 Sep 2. PubMed PMID: 20812010.

Wilson NA, Watkins DI. Is an HIV vaccine possible? Braz J Infect Dis. 2009 Aug;13(4):304-10. Review. PubMed PMID: 20231996; PubMed Central PMCID: PMC2893404.

Martins MA, Wilson NA, Reed JS, Ahn CD, Klimentidis YC, Allison DB, Watkins DI. T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challenge. J Virol. 2010 May;84(9):4352-65. Epub 2010 Feb 17. PubMed PMID: 20164222; PubMed Central PMCID: PMC2863752.

Wilson NA, Keele BF, Reed JS, Piaskowski SM, Mac Nair CE, Bett AJ, Liang X, Wang F, Thoryk E, Heidecker GJ, Citron MR, Huang L, Lin J, Vitelli S, Ahn CD, Kaizu M, Maness NJ, Reynolds MR, Friedrich TC, Loffredo JT, Rakasz EG, Erickson S, Allison DB, Piatak, Jr. M, Lifson JD, Shiver JW, Casimiro DR, Shaw GM, Hahn BH, Watkins DI. Vaccine-induced Cellular Responses Control SIV Replication After Heterologous Challenge J Virol. 2009 Jul;83(13):6508-21. Epub 2009 Apr 29. PMCID: PMC2698536