Pathology and Laboratory Medicine
Aligned research focus:
Organ system/disease focus:
HIV/AIDS, Tuberculosis, co-infections
My research lab is interested in understanding the host immune response to HIV and the effect that HIV-infection has on host immunity to other pathogens. HIV+ immunocompromised individuals cannot mount robust immune responses like individuals who are otherwise healthy. We use nonhuman primates with defined host MHC genetics to understand key factors of immunity against SIV, a virus closely related to HIV. In addition, we are using nonhuman primates to better understand the role of host genetics in containment of Mycobacterium tuberculosis (Mtb) and the factors that contribute to latent reactivation of Mtb in macaques co-infected with SIV.
O'Connor, S. L., E. A. Becker, J. T. Weinfurter, E. N. Chin, M. L. Budde, E. Gostick, M. Correll, M. Gleicher, A. L. Hughes, D. A. Price, T. C. Friedrich, and D. H. O'Connor. (2012) Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection. Journal of Virology. 86(1): 605-609.
*Budde, M.L., *Lhost, J.J., Burwitz, B.J., Becker, E.A., Burns, C.M., O'Connor, S.L., Karl, J.A., Wiseman, R.W., Bimber, B.N., Zhang, G.L., Hildebrand, W., Brusic, V., and O'Connor, D.H. (2011) Transcriptionally abundant Major histocompatibility complex class I alleles are fundamental to non-human primate SIV-specific CD8+ T cell responses. J Virol. 85(7): 3250-61.
O’Connor, S.L., Lhost, J.J., Becker, E.A., Detmer, A.M., Johnson, R.C., MacNair, C.E., Wiseman, R.W., Karl, J.A., Greene, J.M., Burwitz, B.J., Bimber, B.N., Lank, S.M., Tuscher, J.J., Mee, E.T., Rose, N.J., Desrosiers, R.C., Hughes, A.L., Friedrich, T.C., Carrington, M., and O’Connor, D.H. (2010) MHC Heterozygote Advantage in Simian Immunodeficiency Virus-Infected Mauritian Cynomolgus Macaques. Sci Transl Med. 2: 22ra18.