David O’Connor

Associate Professor

Department:

David O'Connor Pathology and Laboratory Medicine

Contact Information:

  • (608) 301-5710

Curriculum Vitae:

David O'Connor's Curriculum Vitae

Other web pages:

Aligned research focus:

Interplay of genetics and immunity to infectious diseases

Organ system/disease focus:

RNA viruses, specifically HIV/AIDS

Research description:

Globally, there are more than 30 million individuals living with HIV/AIDS, a number that is growing by approximately 3 million each year. The overarching goal of my laboratory is to contribute meaningfully to the global response to HIV. Though HIV is ultimately a preventable disease, the sheer number of new HIV infections demonstrates that a prophylactic vaccine is desperately needed to augment existing prevention programs. Most vaccine concepts are prototyped in macaques infected with simian immunodeficiency virus (SIV). Therefore, our laboratory studies both SIV-infected macaques and HIV-infected people. We seek to understand how genetics affects immunity to these viruses, as well as how these viruses evolve in response to host immunity. Recently we have partnered with researchers studying RNA viruses such as dengue, influenza and simian hemorrhagic fever virus to use techniques developed to study HIV/SIV to improve our understanding of genetics, immunity and pathogenesis.

Selected references:

Bimber, B. N., D. M. Dudley, M. Lauck, E. A. Becker, E. N. Chin, S. M. Lank, H. L. Grunenwald, N. C. Caruccio, M. Maffitt, N. A. Wilson, J. S. Reed, J. M. Sosman, L. F. Tarosso, S. Sanabani, E. G. Kallas, A. L. Hughes, and D. H. O’Connor. 2010. Whole-genome characterization of human and simian immunodeficiency virus intrahost diversity by ultradeep pyrosequencing. J Virol 84:12087-12092: PMC2977871.

Lank, S. M., R. W. Wiseman, D. M. Dudley, and D. H. O’Connor. 2010. A novel single cDNA amplicon pyrosequencing method for high-throughput, cost-effective sequence-based HLA class I genotyping. Hum Immunol 71:1011-1017.

Burwitz, B. J., Z. Ende, B. Sudolcan, M. R. Reynolds, J. M. Greene, B. N. Bimber, J. R. Almeida, M. Kurniawan, V. Venturi, E. Gostick, R. W. Wiseman, D. C. Douek, D. A. Price, and D. H. O’Connor. 2011. SIVmac239{Delta}nef vaccination elicits different Tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/Ad5 boost regimen in rhesus macaques. J Virol. 2011 Jan 26. [Epub ahead of print]