Animal Services (Pathology), Wisconsin National Primate Research Center
Aligned research focus:
Neurodegeneration, neuro-oncology, Tumor biology
Organ system/disease focus:
Central and peripheral nervous system
My interest is in studying the role of oxidative stress and metabolism in neurodegeneration and neuro-oncology. My earlier work was on Alzheimer's disease, the progression of which is due to various mechanisms still under investigation. The focus of my research was to understand the role of oxidative stress and Manganese Superoxide Dismutase (MnSOD), an important mitochondrial antioxidant enzyme, in the progression and possibly the initiation of Alzheimer's disease pathology. I used a double knock-in mouse (APP/PS-1) model of Alzheimer's disease and SH-SY5Y neuroblastoma cell line and found that a reduction in the activity of MnSOD precedes the deposition of amyloid beta plaques in the brain of APP/PS-1 mice and contributes to a decrease in mitochondrial respiration and increase in the products of glycolysis. Inactivation of a major anti-oxidant enzyme and subsequent upregulation of glycolysis could play an important role in the progression of Alzheimer's disease and open up innovative ways of treatment and/or prevention.
Caroline MP, Muthuswamy A, Huelsmeyer M, Thompson V, Stein T (2011). Wnt / beta-catenin expression does not correlate with serum alkaline phosphatase concentration in canine osteosarcoma patients. Submitted for publication - PLoS ONE.
Stein T, Holmes K, Thompson V, Muthuswamy A, Huelsmeyer M (2011). Characterization of beta-catenin expression in canine osteosarcoma. Veterinary and Comparative Oncology, 9(1): 65–73.
Behling-Kelly E, Petersen S, Muthuswamy A, Webb JL, Young KM (2010). Neoplastic pleocytosis in a dog with metastatic mammary carcinoma and meningeal carcinomatosis. Veterinary Clinical Pathology, 39(2): 247-252.
Xu Y, Josson S, Fang F, Oberley TD, St Clair DK, Wan XS, Sun Y, Bakthavatchalu V, Muthuswamy A, St Clair WH (2009). RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity. Cancer Research, 69(8): 3267-3271.
Muthuswamy A, Keller JN, Murphy MP, Markesbery WR, Kiningham KK, St Clair DK (2006). ß-Amyloid Mediated Nitration of Manganese Superoxide Dismutase. Implication for Oxidative Stress in an APPNLhxNLh X PS-1P264L/P264L Double Knock-In Mouse Model of Alzheimer's disease. American Journal of Pathology, 168: 1608-1618.