World AIDS Day Research Updates
December 1, 2011
Shelby O'Connor, Ph.D., in the AIDS Vaccine Research Lab
Researchers at the WNPRC AIDS Vaccine Lab have published the following two articles in current issues of the Journal of Virology.
In "Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection", Shelby O'Connor and colleagues at the Wisconsin National Primate Research Center report that there are limits to how many parts of an SIV virus can escape immune recognition during a specific period of time.
In "Pyrosequencing Reveals Restricted Patterns of CD8+ T Cell Escape-Associated Compensatory Mutations in Simian Immunodeficiency Virus", Benjamin Burwitz and scientists at the WNPRC describe the first detailed report of the origin and the complex but coordinated development of mutations that allow CD8+ T-cell escape in individuals infected with the AIDS virus.
Both findings open up new avenues for identifying vaccine targets to fight HIV.