[NOTE: This is the Program and Abstract Book, not the papers themselves which are to be published in the Journal of Medical Primatology in 2002.] San Juan, Puerto Rico at the Caribe Hilton Los Rosales Street Hosted by: The New England Regional Primate Research Center and The Caribbean Primate Research Center Sponsored in part by: The National Center for Research Resources (NCRR) The Office of AIDS Research The National Cancer Institute The National Institute of Allergies and Infectious Diseases ORGANIZING COMMITTEE R. Paul Johnson, Conference Co-Chair Edmundo Kraiselburd, Conference Co-Chair Andrew A. Lackner, Conference Co-Chair Carolyn O'Toole, Committee Member, Conference Coordinator Maria Morales, Committee Member Ingrid Acevedo, Committee Member Kristen Toohey, Graphic Services, Audio/Visual SCIENTIFIC COMMITTEE Local: R. Paul Johnson Edmundo Kraiselburd Andrew A. Lackner Ronald C. Desrosiers Out-Of-Town: Cecilia Cheng-Mayer Nancy Haigwood Preston A. Marx Christopher J. Miller Opendra "Bill" Narayan David I. Watkins NOTE FROM PAGE 1: Preston A. Marx, Ph.D., Editor for the special AIDS issue of The Journal of Medical Primatology, to be published in 2002. This issue will include all abstracts, as well as manuscripts from authors making oral presentations at this symposium. AGENDA: Wednesday, November 7, 2001 Registration and Welcome Reception Thursday, November 8, 2001 Continental Breakfast Opening Remarks: Ronald Desrosiers, Director New England Regional Primate Research Center Edmundo Kraiselburd, Director Unit of Comparative Medicine Office of the Chancellor, MSC Dr. John Rullan, Secretary of Health Commonwealth of Puerto Rico Keynote Address: Bruce D. Walker, Director AIDS Research Center, Massachusetts General Hospital Session I - Virology: Co-Chairs: Mario Stevenson University of Massachusetts Medical Center Ronald Desrosiers New England Regional Primate Research Center Harvard Medical School Invited Presentation by Mario Stevenson: "Pathogenic determinants in primate lentiviral accessory proteins" Abstract 1: "SIV CD4-independence is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity." BA Puffer, S Pohlmann, AL Edinger, MD Sanchez, J Reitter, DD Watry, HS Fox, RC Desrosiers, RW Doms. Abstract 2: "Co-transmission and growth of CCR5 and CXCR4 specific SHIVs after intravaginal or intravenous exposure." JM Harouse, A Gettie, T Eshetu, R Fuller, J Blanchard, C Cheng-Mayer. Abstract 3: "N-linked Glycans in the Vl-V3 Regions HIV-1 89.6 Envelope Protein Modulate Viral Infectivity and Susceptibility to Neutralization." Y Li, BR Cleveland, S-L Hu. Abstract 4: "Specific envelope substitutions associated with rapid progression to AIDS in SIV-infected macaques." H Dehghani. VM Hirsch. Abstract 5: "Interaction of two distinct rhesus DC-SIGN isoforms with primate lentiviruses." Z Chen, Y Huang, X Zhao, L Ba, A Gettie, W Zhang, B-S Hu, DD Ho. Abstract 6: "Distinct immunopathgenesis for SIVmac in Chinese Rhesus: a better non-human primate model for AlDS." B Ling, RS Veazey, A Luckay, C Penedo, K Xu, J Lifson, PA Marx. Abstract 7: "Species-specific variation in SIV disease progression between Chinese and Indian subspecies of rhesus macaque." AM Trichel, M Murphey-Corb. Abstract 8: "Titration of a SIVmac251 stock by vaginal inoculation of Indian- and Chinese-origin rhesus macaques: transmission efficiency, viral loads and antibody responses." ML Marthas, D. Lu, MCT Penedo, AG Hendrickx, CJ Miller. Session II - Immunology: Co-Chairs: David Watkins Wisconsin Regional Primate Research Center R. Paul Johnson New England Regional Primate Research Center Harvard Medical School Invited Presentation by David Watkins: "Viral escape from CTL" Abstract 9: "Frequencies of functional RhCMV- and SlV-specific memory T cells in peripheral blood do not reflect the representation of these cells within lymphoid tissues and extralymphoid effector sites." R Lum, JM Walker, SI Hagen, SW Wong, MK Axthelm, LJ Picker. Abstract 10: "MHC class I alleles associated with disease progression in SIV-infected rhesus macaques." T Muehl, P TenHaaft, F-J Kaup, G Hunsmann, C Stahl-Hennig, U Sauermann. Abstract 11: "Differences between T-cell epitopes recognized after immunization and after infection." TU Vogel, H Horton, DH Fuller, DK Carter, K Vielhuber M Liebl, Tim Shipley,Jim Fuller,Gerd Sutter, V Erfle, L Picker, D Watkins." Abstract 12: "Avidity of CTL influences the rate of viral escape during SIV infection." DH O'Connor, TM Allen, TU Vogel, P Jing, I Desouza, E. Dunphy, C. Melsaether, E. Dodds, B. Mothe, H. Horton, T. Friedrich, K. Westover, A. Hughes, DI Watkins. Abstract 13: "Inclusion of Vpr accessory gene plasmid with vaccines encoding multiple HIV-I antigens markedly reduces vaccine effectiveness and antigen- specific effector T-cell function in vivo resulting in CD4 cell loss and increased viral loads in rhesus macaques." K Muthumani, V Ayyavoo, D Conway, S Kudchodkar, D Zhang, J Kim, J Boyer, L Montaner, K Manson, M Bagarazzi, P Weiner. Abstract 14: "Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus." ST Arron, A Gettie, J Blanchard, DD Ho, L Zhang. Abstract 15: "Dominance of CD8 responses specific for epitopes bound by a single MHC class I molecule during both the acute and chronic phases of viral infect." BR Mothe. H Horton, DK Carter, ME Liebl, S Fuenger, TM.Allen, Skinner, TU Vogel, G Franchini, W Rehrauer, N Wilson, JD Altman, A Haase, LJ Picker, DB Allison, RC Desrosiers, AD Sette, DI Watkins. Abstract 16: "SIV-specific CD8+ T cells traffic to the female genital mucosa and express receptors for inflammatory chemokines." M Cromwell, X Alvarez, JD Altman, A Luster, AA Lackner, RP Johnson. Abstract 17: "Non-activated dendritic cells predominate in lymph nodes of monkeys with AIDS." MI Zimmer, CM Castillo, TA Reinhart, M Murphey-Corb, SM Barratt-Boyes. Abstract 18: "Detailed analysis of CD4+ T helper responses to env and gag proteins of simian immunodeficiency virus reveals a relative lack of broadly reactive CD4+ T helper epitopes in the glycosylated regions of env." S Sarkar, V Kalia, M Murphey-Corb, RC Montelaro Reception and Poster Session Friday, November 9, 2001 Session III - Pathogenesis: Co-Chairs: Malcolm Martin National Institute of Allergy and Infectious Diseases National Institutes of Health Andrew A. Lackner Tulane Regional Primate Research Center Tulane University Health Sciences Center Invited Presentation by Malcolm Martin: "A systemic analysis of the rapid and irreversible CD4+ T cell depletion induced by the highly pathogenic SHIV DH12R." Abstract 19: "Transient early antiretroviral treatment facilitates CD8+ lymphocyte mediated control of pathogenic SIV infection and resistance to homologous and heterologous rechallenge." JD Lifson, JL Rossio, M Piatak Jr, BM Flynn, B Fisher, RC Desrosiers, VM Hirsch, K Reimann, J Schmitz, J Ghrayeb, N Bischofberger, D Wodarz, MA Nowak. Abstract 20: "Gut-associated lymphoid tissue is a primary reservoir for simian immunodeficiency virus in naturally infected sooty mangabeys." SP O'Neil, DC Anderson, C Suwyn, G Niedzielal, J Bradley, DC Montefiori, FJ Novembre, HM McClure. Abstract 21: "Dynamics of T lymphocyte turnover in sooty mangabeys, a non-pathogenic host of simian immunodeficiency virus infection." A Kaur, AF Barabasz, M Rosenzweig, HM McClure, MB Feinberg, RP Johnson. Abstract 22: "Dysregulation of chemokine expression in lymphoid tissues during SlV/DeltaB670 infection of rhesus macaques." TA Reinhart, BA Fallert, M Pfeifer, S Capuano III, P Rajakumar, M Murphey-Corb, CL Fuller, TM Schaefer. Abstract 23: "Activated memory CD4+T cells are the primary target for SIV infection and elimination." G Yang, R Veazey, X Alvarez, L Alexander, I Tham, C Romsey, R Desrosiers, A Lackner. Abstract 24: "Mucosal immunopathogenesis of pediatric AIDS." RS Veazey, AA Lackner. Abstract 25: "Blockade of T-cell costimulation during acute SIV infection in rhesus macaques blunts SIV-specific cellular immune responses but does not protect them from AIDS." DA Garber, G Silvestri, A Fedanov, N Kozyr, A Barry, C Ibegbu, A Carter, D Anderson, X Wang, R Mittler, H McClure, CP Larsen, JD Altman, S Staprans, MB Feinberg. Abstract 26: "Impact of early antiretroviral therapy on SlV-specific CD8+ and CD4+ T responses in SIV-infected rhesus macaques." M-C Gauduin, J Pierce, C Liu, JD Lifson, J Altman, RP Johnson. Abstract 27: "Importance of lymphocyte homing for the development of intestinal lesions in animals infected with SlVmac239/YEnef." MW Elliott, AA Lackner. Abstract 28: "Early events in the neuropathogenesis of SlVsmmPGM infection in M. Nemestrina." S Buch, MS Smith, D Pinson, Z Li, I Adany, F Jia, Y Niu, F Novembre, R Potula, A Kumar, O Narayan. Session IV - Vaccines & Therapeutics: Co-Chairs: Vanessa Hirsch National Institute of Allergy and Infectious Diseases National Institutes of Health Edmundo Kraiselburd Unit of Comparative Medicine Office of the Chancellor, MSC Invited Presentation by Vanessa Hirsch: "Lessons for AIDS vaccine development from macaque models " Abstract 29: "An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants." NF Rose, PA Marx, A Luckay, DF Nixon, WJ Moretto, SM Donahoe, D Montefiori, A Roberts, L Buonocore, JK Rose. Abstract 30: "Generation of cross-reactive neutralizing and protective antibodies in macaques immunized with a modified HIV-1 envelope." C Buckner, I Shrivastava, J Safrit, A Gettie, J Blanchard, J Mascola, C Wild, SW Barnett, L Stamatatos. Abstract 31: "Inclusion of an env protein boost with a DNA/MVA prime-boost vaccine; impact on humoral and cellular immunogenicity and protection from SHIV challenge." TC VanCott, J Cox, P Earl, J Lane, P Luciw, S Himathongkham, E Kuta, J Boyer, S Ratto-Kim, L Frampton, L Steinmeyer, H Beary, N Gomez, S Parrish, D Brown, R Corbin, D Weiner, B Moss, D Birx. Abstract 32: "Adoptive transfer of SIV naive autologous CD4+ cells is sufficient to induce a longterm non progressor status." F Villinger, GT Brice, AE Mayne, P Bostik, K Mori, CH June, AA Ansari. Abstract 33: "DNA vaccine induction of T cell responses prior to infection augments the efficacy of immunotherapy during HAART post-infection." DH Fuller, MS Wu, P Rajakumar, T Allen, S Capuano, JT Fuller, T Shipley, R Rudersdorf, A Sette, JR Haynes, DI Watkins, M Murphey-Corb. Abstract 34: "Mucosal priming of SlV-specific CTL responses in rhesus macaques by the Salmonella type IN secretion system." DT Evans, L-M Chen, J Gillis, K-C Lin, B Harty, GP Mazzara, KG Mansfield, RC Desrosiers, JE Galan, RP Johnson. Abstract 35: "IL-12/GM-CSF co-administration with a SIV VLP DNA prime/protein boost leads to viral control following mucosal SIV challenge in rhesus macaques." I Martinez, Z Israel, F Villinger, M Sidhu, R Stout, D Montefiori, E O'Neill, AA Ansari, M Martinez, E Kraiselburd. Abstract 36: "Inactivated retroviruses with functional envelope proteins serve as platforms for testing molecularly modified Gpl20. LO Arthur, R Benveniste, R Desrosiers, J Hoxie, EN Chertova, JW Bess, LE Henderson, JD Lifson. Abstract 37: "Sterilizing immunity against a simian-human immunodeficiency virus (SHIV) challenge was achieved in 11 pig-tailed macaques following passive transfer of high-titered neutralizing antibodies." Y Nishimura, R Shibata, T Igarashi, N Haigwood, R Plishka, A Buckler-Whit, MA Martin. Abstract 38: "Prevention of SHIV89.6p induced disease in rhesus monkeys after vaccination with recombinant gp120 and a Nef Tat fusion protein formulated in the adjuvant AS02A." N Mathy, K Manson, P Mooij, D Montefiori, D Watkins, J Heeney, M Wyand, J Cohen, C Bruck, G Voss. Abstract 39: "Improved efficiency of DNA vaccination using a new generation of optimized HIV and SlV plasmids." GN Pavlakis, M Rosati, P Eyler, A Valentin, H Trivedi, A Biragyn, LW Kwak, P Markham, R Woodward, A von Gegerfelt, N Miller, BK Felber. Abstract 40: "Efficacy of PRO 2000 gel in a macaque model for vaginal HIV transmission." MG Lewis, W Wagner, J Yalley-Ogunro, J Greenhouse, AT Profy. Banquet Speaker: Jon Cohen Saturday, November 10, 2001 Session V - New Technologies: "Advances in the analysis of cell-mediated immune responses" Chair: Louis Picker Oregon Regional Primate Research Center Invited Presentation by Louis Picker: "Analysis of T cell memory development and homeostasis in rhesus macaques" Abstract 41: "Multilabel confocal microscopy for visualizing SIV and the host immune response in situ." X Alvarez, M Cromwell, G Yang, R Veazey, C Romsey, J MacKey, M Simon, S Klumpp, L Alexander, R Desrosiers, RP Johnson, A Lackner. Abstract 42: "Phenotypic and functional analysis of SIV-specific CD4+ T cells in macaques immunized with attenuated SIV." M-C Gauduin, M Connole, A. Kaur, S. Ahmad, T. Yilma, RP Johnson. Advances in in vivo imaging: Chair: R. Gilberto Gonzalez Massachusetts General Hospital Presentation by Session Chair: R. Gilbert Gonzalez "Neuroimaging of nonhuman primates for the study of the AIDS dementia complex" Abstract 43: "Detailed analysis of live cell antigen acquisition by monkey dendritic cells." LA Harshyne. SC Watkins, A Gambotto, SM Barratt-Boyes. Abstract 44: "Peripheral benzodiazepine receptor expression as a marker of microglial activation in SIV-infected macaques: Implications for neuroimaging." JL Mankowski, SE Queen, PJ Tarwater, RJ Adams, TR Guilarte. Advances in nonhuman primate genomics: Abstract 45: "Old world monkeys in the new age of functional genomics." MJ Korth, K Woodard, MB Agy, RA Feldman, RE Bumgarner, MG Katze. Abstract 46: "Microarray analysis of regulated gene expression in gut lymphoid tissue during primary and asymptomatic SIV infection. MD George, S Sankaran, A Gelli, S Dandekar. 2002 Symposium Preview Chris Miller California Regional Primate Research Center HOW TO OBTAIN: Please contact: Sydney Ann Fingold, Head Librarian New England Regional Primate Research Center, Harvard Medical School Library One Pine Hill Drive - P.O. Box 9102 Southborough, MA 01772-9102 USA E-MAIL: sfingold@hms.harvard.edu WEB SITE: http://www.hms.harvard.edu/nerprc/ PHONE: (508) 624-8028 FAX: (508) 460-1209
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