Edited by Robert J. Handa, Shinji Hayashi, Ei Terasawa, Mitsuhiro Kawata CRC Press Copyright 2002 FROM THE BACK COVER: Neuroplasticity, Development, and Steroid Hormone Action concerns the effects of steroid hormones on brain development, function, and aging. The experimental approaches utilized by the authors range from molecular to behavioral and endocrine to neurobiological. The authors are noted neurobiologists and active researchers from the United States, Japan, and the United Kingdom. With 28 chapters divided into 5 sections, the book focuses on: * Development and differentiation of neuroendocrine systems * Steroid-dependent brain differentiation * Steroid hormones and neuroplasticity in the mature brain * Steroid-mediated mechanisms of cell growth and survival * Regulation of GnRH neurosecretion FEATURES * Provides a comprehensive guide to cutting-edge research in the field of steroid hormone receptors in neurobioloy and neuroendocrinology * Includes experimental approaches from molecular to behavioral * Describes steroid action as a potential tool for clinical treatment * Provides cross-disciplinary examination by distinguished international contributors CONTENTS Introduction: Sexual Differentiation of the Brain: An Historical Perspective 1 Seiichiro Kawashima and Roger A. Gorski 1. Migration of Luteinizing Hormone-Releasing Hormone (LHRH) Neurons: The Road to Reproductive Function 9 Susan Wray 2. Role of Transcription Factors in the Development of the Hypothalamic Neuroendocrine System 21 Hitoshi Kawano, Tetsuo Noda, Shioko Kimura, and Noriko Osumi 3. Steroid Regulation of Cell Populations in the Insect Central Nervous System 31 Susan E. Fahrbach, Kathleen A. Klukas, and Karen A. Mesce 4. Molecular Mechanisms of Thyroid Hormone Action in Brain Development 45 Noriyuki Koibuchi 5. Positioning Estrogen Receptor Alpha-Containing Cells during Hypothalamic Development 59 Stuart A. Tobet, Tammy Dellovade, Keith Parker, and Gregg Homanics 6. The Role of Glucocorticoids and Retinoic Acid in Pituitary Endocrine Cell Differentiation 73 Kinji Inoue, Hideki Goda, Chihiro Mogi, Mikio Tomida, and Shinobu Tsurugano 7. In Vitro and In Vivo Approaches to the Study of the Neuroprotective Actions of Estradiol 81 Phyllis M. Wise, Melinda E. Wilson, Dena B. Dubal, and Shane W. Rau 8. Neuroprotective Effects of Estrogen in Nigral Dopaminergic Neurons 93 Hideyuki Sawada and Shun Shimohama 9. Novel Cerebellar Function: Neurosteroids in the Purkinje Neuron and their Genomic and Nongenomic Actions 101 Kazuyoshi Tsutsui, Kazuyoshi Ukena, and Hirotaka Sakamoto 10. Potential Mechanisms for the Effects of Estrogen on Cognitive Processes: Role of Basal Forebrain Cholinergic Projections 117 Robert B. Gibbs 11. Male Reproductive Defects in Puromycin-Sensitive Aminopeptidase-Deficient Mice, Goku 131 Takashi Takeuchi 12. GnRH Gene Expression: Lessons Learned from Immortalized Cells 141 Mark A. Lawson and Pamela L. Mellon 13. Pulse Generation in LHRH Neurons 153 Ei Terasawa 14. Neuronal Control Circuit for the Gonadotropin-Releasing Hormone Surge in Rats 169 Toshiya Funabashi, Kazuyuki Shinohara, and Fukuko Kimura 15. Electrical Properties of Postnatal GnRH Neurons in the Mouse and Their Regulation by Gonadal Steroids 177 Allan E. Herbison 16. Physiology of GnRH Neurons and Modulation of their Activities by GnRH 191 Yoshitaka Oka and Hideki Abe 17. Electrophysiological Analyses of GnRH Neurons Using a Transgenic Mouse Model 205 F. Edward Dudek, Wendy A. Pouliot, Cathleen Kuchl-Kovarik, R. Anthony DeFazio, Kathryn M. Partin, Robert J. Handa, and Suzanne M. Moenter 18. Novel Estrogen Feedback Associated with Fasting-Induced Suppression of Luteinizing Hormone Secretion 221 Hiroko Tsukamura, Maria Amelita C. Estacio, Beverly A.S. Reyes, and Kei-ichiro Maeda 19. Biochemical, Pharmacological, and Functional Characterization of the Corticosterone Membrane Receptor in an Amphibian: A Brief Review 223 Frank L. Moore 20. Different Subsets of Preoptic Neurons for Proceptive and Receptive Components of Female Rat Sexual Behavior 243 Yasuo Sakuma 21. Animal Models of Experiential Effects on Neural Metabolism: Plasticity in Limbic Circuits: 257 Jon T. Sakata, Ajay Gupta, and David Crews 22. In Vivo and In Vitro Studies on Steroid Hormones Receptors and Cofactors: Tissue Localization in the Brain and Intracellular Dynamics 273 Mitsuhiro Kawata, Mayumi Nishi, Ken-ichi Matsuda, Hiroshi Ogawa, Ikuo Ochiai, and Maki Yoshida 23. Sex Differences in Chronic Stress Effects on Cognitive Function and Brain Neurochemistry 287 Victoria Luine, Kevin Beck, Rachel Bowman, and Meredith Kneavel 24. Do Sex Chromosomal Genes Directly Induce Sexually Dimorphic Neural Development? 301 Arthur P. Arnold, Robert J. Agate, Laura L. Carruth, Megha Patel, William Perlman, Baskaran Ramachandran, and Jun Xu 25. Excitatory GABA as a Mediator of Steroid-Induced Brain Sexual Differentiation 319 Margaret M. McCarthy, Tara S. Perrot-Sinal, Anthony P. Auger, and Micah J. Sickel 26. Progesterone and Sexual Differentiation of the Developing Brain 343 Christine K. Wagner and Princy S. Quadros 27. Transient Expression of Estrogen Receptor in the Developing Rat Brain: A Case in the Facial Nucleus 361 Shinji Hayashi 28. Ontogeny and Molecular Characterization of Estrogen Receptors in the Hippocampus 371 Robert J. Handa, Richard H. Price, Jr., Cheryl A. Butler, and Derek T. Solum Index 393 EDITORS Robert J. Handa is Professor of Anatomy and Neurobiology in the College of Veterinary Medicine and Biomedical Sciences at Colorado State University. He received an M.S in Animal Physiology from the University of Arizona and a Ph.D. in Anatomy and Cell Biology from the University of California, Los Angeles. He served as a postdoctoral fellow at the Oregon Regional Primate Research Center and the Oregon Health Sciences University and as a Faculty member at Loyola University School of Medicine prior to moving his laboratory to Colorado State University. Dr. Handa has authored over 90 articles in a variety of peer-reviewed journals and is the author of a number of review chapters in books. He has served as principal organizer for several international meetings on neurobiology including the Workshop on Steroid Hormones and Brain Function and the U.S./Japan Bilateral Symposium on Neuroplasticity, Development and Steroid Hormone Action. His research interests focus on the molecular and cellular mechanisms of steroid hormone action in the brain. This research program has been funded for the past decade by ongoing grants from the National Science Foundation and the National Institutes of Health. Shinji Hayashi is a professor in the Laboratory of Endocrinology, Graduate School of Integrated Science and Faculty of Science, Yokohama City University, Yokohama, Japan. Dr. Hayashi earned a B.S. degree in Biology (1965) and a Ph.D. degree in Biology (1970) from the Zoological Institute of the University of Tokyo. He spent two years at the Brain Research Institute at UCLA as a postdoctoral fellow (Dr. Roger A. Gorski as a mentor) and then spend seven years as Laboratory Head of Physiology and Endocrinology at the National Cancer Research Institute in Tokyo. In 1979 he moved to Tokyo Metropolitan Institute for Neuroscience (TMIN) where he was Laboratory Head and Chairman of the Department of Anatomy and Embryology. In 2000, he moved to his present affiliation in Yokohama. He is a member of the Society of Behavioral Neuroendocrinology, the Japan Society of Zoology, the Japan Neuroscience Society, the Japan Society of Comparative Endocrinology, and many other local and international academic societies. His research interests concern the hormonal action on developing brain, including sexual differentiation of the brain. He and his research group have a number of publications on topics in this field and in prominent journals. Ei Terasawa is Professor in Pediatrics, University of Wisconsin and Senior Scientist at the Wisconsin Regional Primate Center. She earned a B.S. at the University of Tokyo, a Ph.D. at the Yokohama City University Medical School. She did her postdoctoral training at UC-Berkeley and UCLA. Her research focus is on the neurobiological mechanism of the onset of puberty and the cellular mechanism of pulsatile GnRH release. Dr. Terasawa has authored over 130 publications. She was the principal organizer for the U.S./Japan Joint Symposium on The Cellular and Molecular Action of Steroid Hormones in the Brain and has served on the editorial boards of several journals, including Endocrinology and Neuroendocrinology, as well as on numerous committees at the National Institutes of Health. Mitsuhiro Kawata is Professor in the Department of Anatomy and Neurobiology at Kyoto Prefectural University of Medicine. Dr. Kawata received his M.D. and Ph.D. from Kyoto Prefectural University of Medicine, where he continued on as a professor. He has been a visiting assistant professor at the Rockefeller University and the University of Edinburgh. He has published numerous peer-reviewed articles concerning the molecular regulation of neuropeptide gene expression by steroid hormones. Dr. Kawata was awarded the Kawakami Award in 1989 by the Japan Neuroendocrine Society. WHERE TO ORDER: CRC Press LLC Attn: Order Entry 2000 NW Corporate Blvd. Boca Raton, FL, 33431-9868 USA Phone: 1(800) 272-7737 Fax: 1(800) 374-3401 E-mail: orders@crcpress.com Web site: http://www.crcpress.com PRICE: $139.95(Hardbound) ISBN:0-8493-0962-X
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