Edited by Suresh I.S. Rattan Danish Centre for Molecular Gerontology Department of Molecular Biology University of Aarhus Denmak Biology of Aging and its Modulation Series, Volume 5 Series editor: Suresh I.S. Rattan Kluwer Academic Publishers, 2003 FROM THE BACK COVER After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence. The book will be most useful for researchers, healthcare persons, cosmetologists, and pharmaceutical industry. TABLE OF CONTENTS Editorial: About the series "Biology of aging and its modulation" S. Rattan vi Chapter 1. Modulating aging, longevity determination and the diseases of old age L. Hayflick 1 Chapter 2. The modulation of lifespan by natural selection R. Holliday 17 Chapter 3. Early-life factors modulating lifespan L.A. Gavrilov and N.S. Gavrilova 27 Chapter 4. Selective breeding for slower aging and greater lifespan L. S. Luckinbill 51 Chapter 5. Slowing down cellular aging in vitro I. P. Trougakos, N. Chondrogianni, A. Pimenidou, M. Katsiki, C. Tzavelas, E.S. Gonos 65 Chapter 6. Escaping cellular senescence in vitro R. Wadhwa, P. Polly, A. Nagpal, S. C. Kaul 85 Chapter 7. Stress, cells and tissue aging J.-F. Dierick, C. Frippiat, M. Salmon, F. Chainiaux, O. Toussaint 101 Chapter 8. Hormesis in aging and longevity N. Minois and S.I.S. Rattan 127 Chapter 9. Therapeutic interventions for age-related muscle wasting T. Shavlakadze and M.D. Grounds 139 Chapter 10. Slowing down aging in the skin G. S. Ashcroft and J.J. Ashworth 167 Chapter 11. Antioxidants as modulators E. Le Bourg 183 Chapter 12. Mitochondrial interventions in aging and longevity C. Driver 205 Chapter 13. Hormonal interventions of aging and longevity M.K. Thakur 219 Chapter 14. Effect of melatonin on longevity V.N. Anisimov 239 Chapter 15. Nutritional modulation of aging: effect of caloric restriction M.A. Pahlavani M.L. Hamilton, A. Richardson 261 Chapter 16. Small peptide-associated modulation of aging and longevity V.N. Anisimov and V.Kh. Khavinson 279 Chapter 17. Gene expression profiling to study aging and its modulation S. Welle 303 Index 325 ***************************************************** ISBN: 1402013698 (hardcover) $140.00 USD *Pre-publication price until November 7, 2003 $90.00 USD WHERE TO ORDER: North and South America: Kluwer Academic Publishers Customer Service Department P.O. Box 358, Accord Station Hingham, MA 02018-0358 U.S.A. Tel: (781) 871-6600 Toll Free: (866) 269-9527 Fax: (781) 681-9045 E-mail: kluwer@wkap.com The hours of operation are Monday - Friday, 8:30 am - 5:00 pm, EST. Europe, Asia, Africa, Australia: Kluwer Academic Publishers Customer Service Department P.O. Box 989 3300 AZ Dordrecht The Netherlands Tel: (+31) 78 657 60 50 Fax: (+31) 78 657 62 54 E-mail: services@wkap.nl The hours of operation are Monday - Friday, CET: 8.30 - 17.00 hrs. Direct link to catalog entry: http://www.wkap.nl/prod/b/1-4020-1369-8 Posted Date: 11/10/03
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