Edited by Jerald Silverman Mark A. Suckow Sreekant Murthy CRC Press Copyright 2000 FROM BACK COVER: Since its establishment by federal regulation in the mid-1980s, the Institutional Animal Care and Use Committee has evolved as the premier instrument of animal welfare oversight within research institutions in the U.S. Its mission, in part, is to ensure that investigators, research technicians, animal care personnel, and others are adequately trained to conduct research with animals in a proper and humane manner. But equally important is that the IACUC itself be adequately trained with regard to the successful interpretation and implementation of regulations and guidelines for proper animal care and use. THE IACUC HANDBOOK focuses on both basic and advanced concerns of those who participate in activities of Institutional Animal Care and Use Committees. Exhaustive in its content and written by leading authorities in the field, this handbook addresses those questions and problems that often confront IACUCs, and gives accurate, succinct answers. Information is provided in "Question and Answer" format, with the authors offering their personal opinions against a background of regulatory information. With the role and impact of the Institutional Animal Care and Use Committee expected to grow in scope and complexity, The IACUC Handbook provides a foundation for those attempting to understand and implement the many and varied responsibilities of this committee. FEATURES … Provides "Question and Answer" format for common and complex problems facing IACUCs … Includes "regulatory" sections reviewed by staff at NIH/OPRR and APHIS/AC for consistency with the Public Health Service Policy on Humane Care and Use of Laboratory Animals and the USDA Animal Welfare Act Regulations … Addresses issues from a regulatory perspective, from the opinions of experienced professionals in the field, and in the form of responses to informal surveys … Describes IACUC functions-e.g., justifications required for animal use, inspections of laboratories, personnel training … Offers concise, easy to find information by subject groupings and cross references CONTENTS Abbreviations Used in This Book xix 1. Origins of the IACUC 1 Harry Rozmiarek 2. Circumstances Requiring an IACUC 11 Richard C. Van Sluyters, Jane E. Simpson, and Ralph B. Dell 3. Creation of an IACUC 19 Richard C. Van Sluyters, Jane E. Simpson, and Ralph B. Dell 4. Reporting Lines of the IACUC 31 Richard C. Van Sluyters, Jane E. Simpson, and Ralph B. Dell 5. General Composition of the IACUC and Specific Roles of the IACUC Members 35 Christian E. Newcomer 6. Frequency and Conduct of Regular IACUC Meetings 59 Sreekant Murthy 7. General Format of IACUC Protocol Forms 75 Christian E. Newcomer 8. Submission and Maintenance of IACUC Protocols 87 Farol N. Tomson 9. General Concepts of Protocol Review 107 Ernest D. Prentice and Gwenn S. F. Oki 10. Amending IACUC Protocols 133 Diane J. Gaertner and Kathleen D. Moody 11. Continuing Review of Protocols 141 Gwenn S. F. Oki 12. Justification for the Use of Animals 149 Joseph S. Spinelli 13. Justification of the Number of Animals to Be Used 167 Edward J. Gracely 14. Animal Acquisition and Disposition 179 Michael J. Huerkamp and David R. Archer 15. Animal Housing and Use Sites 207 Cynthia Gillett 16. Pain and Distress 221 Paul Flecknell and Jerald Silverman 17. Euthanasia 251 Peggy J. Danneman 18. Surgery 277 Elizabeth J. Dawe 19. Antigens, Antibodies, and Blood Collection 303 Harold F. Stills, Jr. 20. Occupational Health and Safety 319 Stefan Wagerer and Susan Stein 21. Personnel Training 345 Howard G. Rush 22. Academic Freedom and Proprietary Information 365 Sallie Thieme Sanford and Lisa A. Vincler 23. General Concepts of the Facility Inspection and Program Review 385 Stephen K. Curtis 24. Inspection of Animal Housing Areas 401 Patricia A. Ward 25. Inspection of Individual Laboratories 419 Neil S. Lipman and Scott E. Perkins 26. Inspection of Surgery Areas 431 Scott E. Perkins and Neil S. Lipman 27. Assessment of Veterinary Care 447 Mark A. Suckow and Bernard J. Doerning 28. Laboratory Animal Enrichment 465 Kathryn A. L. Bayne 29. Animal Mistreatment and Protocol Noncompliance 481 Jerald Silverman Appendix A. Animal Welfare Act 505 Appendix B. Animal Welfare Act Regulations 507 Appendix C. Health Research Extension Act of 1985 517 Appendix D. Public Health Service Policy on Humane Care and Use of Laboratory Animals 521 Appendix E. U.S. Government Principles for the Utilization And Care of Vertebrate Animals Used in Testing, Research,and Training 531 Index 533 WHERE TO ORDER: CRC Press-Lewis Publishers-St. Lucie Press 2000 Corporate Blvd. NW Boca Raton, FL 33431-9869 Attention: Kathryn Lewis E-mail: klewis@crcpress.com Phone: 1-800-272-7737 Ext. 2272 Fax: 1-877-868-3083 Web: http://www.crcpress.com PRICE: $59.95 (hardcover) ISBN 0-8493-1685-5
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