INTRODUCTION TO FLUORESCENCE IN SITU HYBRIDIZATION PRINCIPLES AND CLINICAL APPLICATIONS Edited by Michael Andreeff, M.D., PH.D. Daniel Pinkel, PH.D. Wiley-Liss A John Wiley & Sons, Inc., Publication 2000 CONTENTS Contributors IX PART I. PRINCIPLES AND TECHNIQUES 1. Fluorescence In Situ Hybridization Daniel Pinkel 2. Fluorescence Microscopy for Quantitative Fluorescence In Situ Hybridization Analysis Hans J. Tanke 3. Chromosome Microdissection Michael Bittner, Xin-Yuan Guan, Ji Zhang, Ann Burgess, Paul S. Meltzer, and Jeffrey M. Trent 4. Multicolor Fluorescence In Situ Hybridization Techniques Larry E. Morrison and Mona Legator 5. Analysis of Structure and Function by High-Resolution Visual Mapping of Extended DNA Bradford Windle, Irma Parra, and Emilio Silvas PART II. APPLICATION TO HUMAN CANCER A. Solid Tumors 6. Fluorescence In Situ Hybridization Analysis of Prostate Cancer James A. Brown and Robert B. Jenkins 7. Interphase Cytogenetics of the HER-2/neu Oncogene in Breast Cancer Giovanni Pauletti and Dennis J. Slamon 8. Characterization of Multistep Tumorigenesis by In Situ Hybridization Julie G. Izzo and Walter N. Hittelman 9. Genetic Progression of Cancer by Comparative Genomic Hybridization Olli-Pekka Kallioniemi, Frederic Waldman, T. Visakorpi T. Kuukasjarvi, M. Tanner, T. Nishizaki, M. Tirkkonen, A. Kallionoemi, and J. Isola 10. Detection and Characterization of Micrometastases: Slide-Based Rare Event Analyses Maria G. Pallavicini, D. Moore II, V. R. Litle, and P. Mueller B. Hematologic Malignancies 11. Fluorescence In Situ Hybridization of Myeloid Leukemias: Implications for Molecular Biology, Biology, and Therapy Michael Andreeff and Angela Goodacre 12. Fluorescence In Situ Hybridization of Lymphoproliferative Malignancies Anas Younes, Susan Escudier, and Michael Andreeff 13. Genotype and Phenotype of a Single Cell Sakari Knuutila 14. Inter-Alu-PCR-Generated Fluorescence In Situ Hybridization Probes for the Analysis of Leukemia Ying Zhao, Louis Ramagli, David Seong, Hagop Kantarjian, and Michael J. Siciliano PART III. APPLICATION TO GENETIC ANALYSIS A. Environmental Effects 15. Chromosome Painting and Comparative Genomic Hybridization: Application in Identification of Structural and Numerical Abnormalities in Lymphohematopoietic and Solid Tumors Suresh C. Jhanwar 16. Radiation Biodosimetry Using Fluorescence In Situ Hybridization Analysis of Chromosomal Aberrations Ronald H. Jensen 17. Applications of Fluorescence In Situ Hybridization in Genetic Toxicology M. J. Schuler, D. S. Rupa, and D. A. Eastmond 18. Multiprobe Fluorescence In Situ Hybridization Methods for Detecting Chromosomally Defective Sperm in Mice and Humans Andrew J. Wyrobec and Xiu R. Lowe 19. Rapid Prenatal Diagnosis of Chromosomal Aneuploidies by Fluorescence In Situ Hybridization: Clinical Experience on 10,000 Specimens Brian E. Ward, Steven L. Gersen, Robert Theve, Mary Wright, and Michael P. Carelli 20. Detecting Fetal Trisomy by Fluorescence In Situ Hybridization Analysis of Cells Enriched from Maternal Blood Joe Leigh Simpson, Farideh Z. Bischoff, Dorothy E. Lewis, and Sherman Elias Index FROM THE BACK COVER: Fluorescence In Situ Hybridization (FISH) has become an essential tool in the diagnosis and management of a variety of solid tumors and hematologic malignancies in the clinical setting, as well as an aid in the identification of particular genetic disorders. Introduction to Fluorescence In Situ Hybridization provides a solid groundwork in the basic principles and techniques of FISH and covers in detail the applications of this technology to cancer in humans, including tumorigenesis, prostate and breast tumors, myeloid leukemias, and lymphoproliferative malignancies. The final section of the book is devoted to the applications of FISH techniques to genetic analysis. This incorporates radiation biodosimetry in chromosomal aberrations, genetic toxicology, and multiprobe methods for detecting chromosomally defective sperm in humans and mice, plus rapid prenatal diagnosis of chromosomal aneuploidies and detection of fetal trisomy. Edited by two leading basic and clinical investigators in the field, with state-of-the-art contributions from expert subspecialists, and featuring over 200 color illustrations, Introduction to Fluorescence in Situ Hybridization is an essential reference for clinicians and investigators in oncology, genetics, and cytometry. WHERE TO ORDER: John Wiley & Sons, Inc. 1 Wiley Dr. Somerset, NJ, 08875-1272 U.S.A. Phone: 800-225-5945 Fax: 732-302-2300 Price: $225 Cloth, ISBN: 0471013455
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