Edited by Thomas von Zglinicki Professor of Cellular Gerontology University of Newcastle Henry Wellcome Laboratory for Biogerontology Newcastle General Hospital Newcastle upon Tyne United Kingdom Biology of Aging and its Modulation Series, Volume 1 Series editor: Suresh I.S. Rattan Kluwer Academic Publishers, 2003 FROM THE BACK COVER During the1ast 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmaceutical, nutraceutical and health-care industries. TABLE OF CONTENTS Editorial: About the series "Biology of aging and its modulation" S. Rattan vii Preface ix Chapter 1. Free radical production and antioxidant defense: a primer Nicolle Sitte, Thomas Yon Zglinicki 1 Chapter 2. Oxidative DNA damage and repair - implications for aging Erling Seeberg 11 Chapter 3. Oxidative damage to proteins Nicolle Sitte 27 Chapter 4. Ageing rate, mitochondrial free radical production and constitutive sensitivity to lipid peroxidation: insights from comparative studies Reinald Pamplona, Gustavo Barja 47 Chapter 5. Genomic instability in human premature aging Vilhelm A. Bohr, Patricia L. Opresko 65 Chapter 6. Oxidative damage, somatic mutations and cellular aging Rita A. Busuttil, Miguel Rubio, Martijn E.T. Dolle, Judith Campisi, Jan Vijg 79 Chapter 7. Mitochondria and aging Martin Barron, Doug Turnbull 91 Chapter 8. Biological clocks in the aging cell Petra Boukamp 107 Chapter 9. Telomeric damage in aging Thomas von Zglinicki 121 Chapter 10. Probing the in vivo relevance of oxidative stress in aging using knockout and transgenic mice Florian L. Muller, James Mele, Holly Van Remmen, Arlan Richardson 131 Chapter 11. Non-oxidative modification of DNA and proteins Alan R. Hipkiss 145 Chapter 12. Transcriptional and translational dysregulation during aging Suresh I.S. Rattan 179 Chapter 13. Metabolic regulation of gene silencing and life span Haim Y. Cohen, Kevin J. Bitterman, David A. Sinclair 193 Chapter 14. The proteasome in aging Geraldine Carrard, Bertrand Friguet 213 Chapter 15. Aging and lysosomal degradation of cellular constituents Alexei Terman, Ulf T. Brunk 23 Index 243 ***************************************************** ISBN: 1402017383 (hardcover) $138.00 USD WHERE TO ORDER: North and South America: Kluwer Academic Publishers Customer Service Department P.O. Box 358, Accord Station Hingham, MA 02018-0358 U.S.A. Tel: (781) 871-6600 Toll Free: (866) 269-9527 Fax: (781) 681-9045 E-mail: kluwer@wkap.com The hours of operation are Monday - Friday, 8:30 am - 5:00 pm, EST. Europe, Asia, Africa, Australia: Kluwer Academic Publishers Customer Service Department P.O. Box 989 3300 AZ Dordrecht The Netherlands Tel: (+31) 78 657 60 50 Fax: (+31) 78 657 62 54 E-mail: services@wkap.nl The hours of operation are Monday - Friday, CET: 8.30 - 17.00 hrs. Direct link to online catalog entry: http://www.wkap.nl/prod/b/1-4020-1738-3 Posted Date: POSTED DATE GOES HERE
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