University of California, Davis
Davis, CA 95616
Phone: (916) 752-0420
FAX: (916) 752-8201
The center is located on a 300-acre tract that is 3 miles from
the main campus of the University of California, Davis. The
university administers the center and provides its academic
setting.
Center Director
Andrew G. Hendrickx, Ph.D.
Principal Investigator
Frederick A. Murphy, D.V.M., Ph.D.
Dean, School of Veterinary Medicine
University of California, Davis
Contact
Jenny Short, research services manager, specimens
supplied to outside investigators (916) 752-7169
Andrew G. Hendrickx, Ph.D., services for collaborating
scientists, (916) 752-0420; E-mail: aghendrickx@ucdavis.edu
Basic Research Mission
Studies of the effects of environmental influences on human
health and basic biological approaches to a better understanding
of a variety of human and animal diseases.
Current Research
Behavior and Neurobiology =
Describing the sources of social order in various species of
primates, and analyzing the underlying regulatory processes and
their contributions to animal well-being and reproductive
success. The discipline also encompasses clinically relevant
conditions involving the brain and behavior, such as the aging
process and AIDS.
Developmental and Reproductive Biology
Normal and abnormal aspects of prenatal development, with
particular emphasis on embryotoxic effects of certain agents that
are likely to result in embryonic abnormalities during human
pregnancy. Other projects concern sperm function and transport in
the uterus and oviduct, gamete interaction, early embryogenesis
in an in vitro fertilization system, mechanisms of zinc
deficiency in abnormal development, and cellular biology of the
placenta and fetal membranes.
Respiratory Diseases
Effects of air pollutants and disease on the respiratory system;
lung growth and aging; pulmonary immunopathology.
Virology and Immunology
Special emphasis is placed on retroviruses and immunodeficiency
diseases. Studies are designed to better understand, treat, and
prevent AIDS, and to produce retrovirus-free nonhuman primates. =
Research Resources
Primate Medicine
Maintenance of colony health; programs in preventive medicine;
research services such as surgery, radiology, medicine, and
consultation; domestic breeding; research on spontaneous
diseases.
Primate Pathology
Monitoring and defining health problems; research on
spontaneousdiseases.
Resources Provided
To Outside Investigators
Specimens
Organs and tissues are provided when available; other biological
samples are provided on special request. Costs of shipping,
collection, and processing are charged to the requestor.
To Collaborating Scientists
Scientists wishing to conduct research at the center must have
their projects reviewed and approved by the center director,
scientific advisory committee, and campus animal care review
committee. The center's services are available to collaborating
scientists on a fee-for-service basis. Services include:
Primate Medicine
Preventive medicine and epidemiologic evaluation; surgery;
radiology; therapeutics; specialized medical procedures.
Diagnostic Pathology and Clinical Laboratory Services
Bacteriology, biochemistry, hematology, immunology, parasitology,
pathology, virology.
Electron Microscopy
Transmission electron microscopy.
Inhalation Toxicology
Inhalation chambers are available.
Data Services
Colony database system.
Animals
Center breeding colony: Macaca fascicularis, M. mulatta.
Center research colony: Callicebus moloch, M. mulatta, M.
fascicularis, Saimiri sciureus.
New England Regional Primate Research Center
One Pine Hill Drive, P. O. Box 9102
Southborough, MA 01772-9102
(508) 624-8002
FAX: (508) 460-0612
The center is located on 140 acres in Southborough,
Massachusetts, about 30 miles from Boston. Harvard University
administers the center and provides its academic setting.
Center Director
Ronald D. Hunt, D.V.M.
Principal Investigator
Daniel C. Tosteson, M.D.
Contact
Ronald D. Hunt, D.V.M., (508) 624-8002
E-mail: rhunt@warren.med.harvard.edu
Norval W. King Jr., D.V.M., associate director for research,
(508) 624-8157
Basic Research Mission
Infectious diseases (particularly simian lentivirus-induced
diseases), immunology, oncogenic herpesviruses, primate
pathology, behavioral biology, cardiovascular disease, and
genetics.
Current Research
Microbiology
Use of simian immunodeficiency virus (SIV) as a model for AIDS in
rhesus monkeys; molecular determinants of AIDS pathogenesis;
strategies for vaccine development; mechanisms of
herpesvirus-induced lymphomas in New World primates.
Comparative Pathology
Spontaneous diseases of nonhuman primates; pathogenesis of simian
acquired immunodeficiency syndrome; hemolytic anemia of owl
monkeys; cytomegalovirus-related diseases of macaques; chronic
colitis in marmosets; gastroenteric and neurological diseases of
macaques.
Behavioral Biology
Behavioral pharmacology; neurochemistry; primatology; drug
dependence and abuse; neurodegenerative disease;
pharmacotherapeutics; neuropsychiatric disorders.
Immunology
Cell-mediated immunity to AIDS viruses; evaluation of the
majorhistocompatibility complex of primates.
Cardiovascular Medicine
Physiology; biomedical engineering; biochemistry; comparative
studies on the control of cardiovascular function in normal and
disease states.
Resources Provided
To Outside Investigators
Specimens
Tissue specimens, organs, blood, skeletal structures, viral
specimens, etc. Animals for approved research projects are
provided from breeding colonies or other sources as required.
Costs are normally assumed by the individual requesting the
specimens.
To Collaborating Scientists
Scientists wishing to conduct research at the center must have
projects reviewed and approved by the center director, executive
committee, and institutional animal care and use committee. A
brochure explaining the collaborative research program is
available from the center. Some services are provided
withoutcharge, some on a fee basis. They include:
Primate Medicine
Veterinary services; clinical and experimental surgical and
radiographic services; endoscopy; veterinary hospital and
intensive care; timed primate mating; group macaque housing;
primate nursery; BL3 biocontainment facility; central
sterilization and cage washing; diet kitchen.
Comparative Pathology
Necropsies; electron microscopy; cytogenetics; clinical pathology
and hematology; biochemical analyses of various body fluids.
Microbiology
Isolation of viral and bacterial agents.
Animals
Macaca mulatta, M. fascicularis, M. arctoides, M. cyclopis, Aotus
trivirgatus, Saguinus oedipus, Callithrix jacchus, Saimiri
sciureus. Animals with exceptional characteristics (specially
conditioned, specific-pathogen-free, known age or genealogy,
surgically altered, timed pregnancy) may be provided when
available.
Oregon Regional Primate Research Center
505 N. W. 185th Avenue
Beaverton, OR 97006
(503) 645-1141
FAX: (503) 690-5532
The center is located on a 247-acre tract 12 miles from downtown
Portland. The Medical Research Foundation of Oregon administers
the center and the Oregon Health Sciences University serves as
its academic host.
Center Director
M. Susan Smith, Ph.D.
Principal Investigator
Peter O. Kohler, M.D.
President
Oregon Health Sciences University
Contact
M. Susan Smith, Ph.D.
P. Michael Conn, Ph.D., associate director
Basic Research Mission
Reproductive sciences; neuroscience; metabolic and infectious
diseases.
Current Research
Reproductive Sciences
Control of folliculogenesis and the corpus luteum; factors that
control sperm motility and maturation; neuroendocrinology;
hormonal control of parturition; steroid receptors in primate
reproductive tract and brain tissues; implantation; in vitro
fertilization; hormonal control of peptide and catecholamine gene
expressions.
Neuroscience
Neurological processes involved in regeneration of neural tissue;
interactions between neural and immune systems; factors
controlling differentiation and growth of neurons and glia;
degenerative diseases.
Primate Medicine
Therapeutic modification of atherosclerosis; human and animal
models related to antibody synthesis; retrovirus infections in
macaques.
Resources Provided
To Outside Investigators
Specimens
Tissue specimens, organs, etc., are provided when available.
Costs are normally assumed by the individual requesting the
specimens.
To Collaborating Scientists
Scientists wishing to conduct research at the center must have
their projects reviewed and approved by the animal care and use
committee and the associate director for research. Some services
are provided without charge, some on a fee basis. They include:
Medical Services
Physiological data and surgical specimens; cardiology; recovery
of animals for future projects.
Colony Operations
Primates, guinea pigs, mice, hamsters, rats, rabbits.
Pathology
Necropsies, tissue distribution, consultation.
Electron Microscopy
Scanning and transmission electron microscopy.
Data Processing
Prime 9755 computer with remote terminals; comprehensive animal
information system; consultation and support on statistical
processing; extensive radioimmunoassay support.
Library
7,250 books; 12,900 bound journals; 250 journal subscriptions;
MEDLARS searching services; PriMed database; Internet.
Radioimmunoassay Laboratory
Steroid and pituitary protein hormone RIA.
Medical Illustrations and Photography
Animals
Macaca nigra, M. fuscata, M. mulatta, M. nemestrina; Cebus
albifrons, C. apella. Includes an outdoor troop (more than 200)
of M. fuscata and a colony of 1,700 M. mulatta. =
Tulane Regional Primate Research Center
18703 Three Rivers Road
Covington, LA 70433
(504) 892-2040 x 201
FAX: (504) 893-1352
The center is located on 500 acres near Covington, Louisiana, 35
miles from the main Tulane University campus in New Orleans. =
Tulane University administers the center and provides its
academic setting.
Center Director
Peter J. Gerone, Sc.D.
Principal Investigator
John C. LaRosa, M.D.
Chancellor, Tulane University Medical Center
Contact
Peter J. Gerone, Sc.D.
Gary B. Baskin, D.V.M., associate director for research
Basic Research Mission
Infectious diseases, physiology, urology research, and primate
behavior.
Current Research
Microbiology
Testing of antiviral compounds; experimental infections using
Mycobacterium leprae, herpesviruses, retroviruses, and simian
viruses; molecular virology and basic immunology of infectious
diseases and cancer. A particular focus is on AIDS research.
Parasitology
Biology of filarial and malarial infections; Lyme borreleosis in
rhesus monkeys; parasitic diseases of nonhuman primates.
Urology
Pyelonephritis; cystitis; chronic prostatitis and benign
prostatic hyperplasia; bladder physiology; male fertility.
Resources Provided
To Outside Investigators
New Technology/Procedures/Services
Laparoscopy, ultrasound.
Specimens
Tissue specimens, organs, etc., are provided when available.
Costs are normally assumed by the individual requesting the
specimens.
To Collaborating Scientists
Scientists who want to conduct research at the center must have
their projects reviewed and approved by the center director,
scientific advisory committee, and the animal care and use
committee if experimental animals are involved. The center's
services are provided to collaborating scientists on varying
bases. Some are provided without charge, some on a fee basis.
They include:
Animal Care
General veterinary care of experimental animals; technical
assistance for procedures involving animals; husbandry and
breeding of nonhuman primates; nursery, surgery, and x-ray
services.
Pathology
Necropsies, histopathology, clinical pathology, bacteriology,
hematology, clinical chemistry, and electron microscopy.
Parasitology Services
Science Information Service
Includes MEDLINE, SDLINE, CATLINE, and CANCERLINE.
Medical Illustration
Animals
Macaca mulatta, M. fascicularis, M. arctoides, M. nemestrina,
Erythrocebus patas, Saimiri sciureus, Cercopithecus aethiops,
Cercocebus atys atys, Aotus trivirgatus, Papio spp.
Washington Regional Primate Research Center
University of Washington
I-421 Health Sciences SJ-50
Seattle, WA 98195
(206) 543-0440
FAX: (206) 685-0305
The center is located in the Warren G. Magnuson Health Sciences
Center of the University of Washington in Seattle.
Acting Center Director
William R. Morton, V.M.D.
Principal Investigator
Milo Gibaldi, Ph.D.
Chair, Board of Health Sciences Deans
University of Washington
Contact
William R. Morton, V.M.D. =
Primate Information Center (206) 543-4376; FAX: (206) 685-0305;
E-mail: jackiep@bart.rprc.washington.edu
Primate Supply Information Clearinghouse: (206) 543-5178; =
FAX: (206) 685-0305; E-mail: cathydj@bart.rprc.washington.edu
Tissue Distribution: (206) 543-6999; FAX: (206) 685-0305; =
E-mail: jwhite@bart.rprc.washington.edu.
Basic Research Mission
Biomedical research on primates, with special emphasis in
neurological sciences, cardiovascular function, disease models,
developmental biology, endocrinology and metabolism, AIDS,
immunogenetics, and virology.
Current Research
Core Staff
Primate neuroanatomy; functional relations between precentral
cortical cells and muscle; vestibular and oculo-motor
interactions; molecular structure of neuronal membranes;
developmental psychology; central neural control of
cardiovascular system; genetic regulation of B-cell function;
primate major histocompatibility complex; viral translation;
AIDS-related model development, pathogenesis, recombinant
vaccines, and antiviral agents.
Affiliated Staff
Neurological Sciences
Structure and development of monkey visual cortex; auditory
physiology; retinal development.
Cardiovascular Disease and Function =
Arterial smooth muscle cells in atherosclerosis; evaluating blood
compatibility of biomaterials; fetal hemoglobin synthesis.
Disease Models
AIDS; antiviral drugs; fetal alcohol syndrome; immunodeficiency
syndromes; parkinsonism; venereal disease; experimental allergic
encephalomyelitis; Chlamydia; chancroid; Toxoplasma pathogenesis.
Developmental Biology
Hyaline membrane disease; respiratory distress syndrome; visual
development; primate vocalization; effect of epileptic drugs on
development.
Endocrinology and Metabolism Research
Reproductive physiology; regulation of glucagon; role of
somatostatin in physiology and control of somatostatin secretion;
methanol effects; methylmercury effects; parenteral nutrition;
bone loss and gain; diabetes endocrine research.
Transplantation and Prosthesis Development
Bone marrow transplantation; lung transplantation;
neurotransplantation; cochlear prosthetics; arterial graft
development; stem cell transplantation. =
Resources Provided
To Outside Investigators
New Technology/Procedures/Services
A computer database of more than 35,000 bibliographic records
(1985 to the present) of scientific literature on nonhuman
primates is available for lease on MS-DOS machines. This database
includes full citation and indexing information.
Primate Information Center
Develops indexes of comprehensive, worldwide bibliographic
information regarding biomedical research on nonhuman primates.
Provides published and custom bibliographies.
Primate Supply Information Clearinghouse =
Provides communication links between U.S. scientists in need of
primates or tissues and institutions that can meet their needs by
telephone and through weekly publication of the New Listings
Bulletin. A registry of primate colonies and special services is
being developed.
Tissue Distribution Program
Provides blood and tissue specimens to investigators throughout
the United States.
To Collaborating Scientists
Scientists wishing to conduct research at the center must have
their projects reviewed and approved by the center director,
executive committee, and the vice president for health sciences.
Services include:
Pathology
Necropsies, histopathology.
Scientific Illustration and Editing
Neurohistology
Immunologic Typing
Primate Colony Division
Primate health care, surgical procedures, x-ray facilities,
clinical laboratory, round-the-clock nursery care, computerized
genealogic and clinical records.
Bioengineering
Instrumentation development, computer programming.
Animals
Macaca fascicularis, M. mulatta, M. nemestrina, Papio
cynocephalus.
Collections
Slides of lung development in fetal, known-age M. nemestrina;
2,000 dental casts on 200 M. nemestrina; developmental data on
400 macaque infants, including anthropometric measurements, heart
rate, respiration, body temperature, diurnal activity, fluid
intake, and weight gain; developmental data on social behavior of
500 macaque infants 1 to 7 months old; videotapes of labor and
delivery of 100 M. nemestrina; learning assessment data on 100 M.
nemestrina infants; computerized historical data on 6,500
animals, including 70,000 weight records, 22,000 breeding
records, 21,000 hematologic records, and 13,500 disease and
necropsy records.
Wisconsin Primate Research Center
1223 Capitol Court
Madison, WI 53715-1299
(608) 263-3500
FAX: (608) 263-4031
The center occupies two adjacent four-story buildings and one
three-story building (about 80,000 square feet total) on the
University of Wisconsin-Madison campus, and a 5,000-square-foot
research and breeding facility at the Vilas Park Zoo that houses
up to 200 animals. The university administers the center and
provides its academic setting.
Center Director
Joseph Kemnitz, Ph.D.
Principal Investigator
John D. Wiley, Ph.D.
Dean, University of Wisconsin Graduate School
Contact
Joseph Kemnitz, Ph.D., (608) 263-3500.
Larry Jacobsen, head of library services at the WRPRC Library,
about electronic access to the list: (608) 263-3512; FAX: (608)
263-4031; E-mail: jacobsen@primate.wisc.edu; or write the WRPRC
Library
Basic Research Mission
Fundamental research in primate biology related to human and
animal health. There are six research groups, with 120 core and
affiliate doctoral-level staff. =
Current Research
Reproduction =
Hormonal control of implantation and the maintenance of
pregnancy; factors regulating follicle maturation; in vitro
fertilization; molecular regulation of embryonic hormones.
Neurobiology
Effects of female sex hormones on brain chemistry and behavior;
mechanisms involved in the initiation of puberty; regulation of
the GnRH pulse-generating system; visual development.
Physiological Ethology
Control mechanisms of gonadotropin secretion, especially the role
of the hypothalamus in reproductive cycles; hormonal regulation
of behavior in group-living primates; primate ecology and
conservation biology.
Psychobiology
Developmental behavior; stress and environmental influences on
the immune system.
Clinical Biomedicine
Ophthalmology; metabolic diseases; genetics; experimental
pathobiology.
Aging
Changes in hormonal, nervous and visual systems associated with
aging in nonhuman primates; caloric restriction;
neurodegeneration.
Immunology and Virology
Persistence of infection; immunotherapy; transmissions to
trophoblast and to the central nervous system.
=
Resources Provided
To Outside Investigators
New Technology/Procedures/Services
PRIMATE-TALK, an electronic mail listserver, is an open forum for
discussion of primatology and related subjects. It is open to
electronic mail users worldwide who are interested in nonhuman
primates; currently there are more than 500 members in 30
countries. Subject matter may include, but is not limited to,
news items, meeting announcements, research issues, information
requests, veterinary/husbandry topics, job notices, animal
exchange information, and book reviews. People with Internet,
Bitnet, or UUCP addresses can communicate with PRIMATE-TALK.
Users of other networks should contact the WRPRC. To join
PRIMATE-TALK, send a message to
primate-talk-request@primate.wisc.edu. Messages to the list are
sent to primate-talk@primate.wisc.edu. =
The WRPRC Library also coordinates PRIMATE INFO NET (PIN), an
Internet Gopher server for people interested in primatology.
Resources accessible in PIN include:
* A taxonomy of the primates
* Laboratory Primate Newsletter (LPN; current issue) =
* A list of topical bibliographies from the Primate
Information Center (PIC)
* Information on ordering WRPRC audiovisual materials
* Current pricing for PIC database searches
* The Primate-Talk directory
* Information on accessing archives of Primate-Talk
LPN
* Information about the Primate Supply Clearinghouse
* A gateway to Envirolink
* Animal Welfare Act and Amendments
* Gorilla ethograms
* Other information pertinent to the field
PIN Access http://www.primate.wisc.edu.pin
The WRPRC Library published the second edition of the
International Directory of Primatology (250 pp., spiral bound) in
June 1994. Its purpose is to enhance communication among the many
organizations and individuals involved in primate research,
conservation, and education.
Specimens
Tissue specimens, organs, and other biological materials. Costs
are normally assumed by the individual requesting the specimens.
To Collaborating Scientists
The center actively encourages researchers from the midwest
region and elsewhere nationally and internationally to use its
facilities and services and to conduct collaborative studies.
Scientists wishing to conduct research must have their projects
reviewed and approved by the center director and advisory
committees and have independent funding to cover costs. The
center's services are available to collaborating scientists. Some
are provided without charge, some on a fee (chargeback) basis.
They include:
Bioservices
Clinical laboratory tests, including assay procedures for
adrenal, gonadal, and pituitary hormones; surgery; breeding
colony; baseline data service on reproductive behavior; molecular
procedures (polymerase chain reaction [PCR] assays, in situ
hybridization).
Colony Management
Maintenance; veterinary medicine; assistance in drug
administration, specimen collection, and animal handling;
environmental enrichment.
Computer Services
Colony record system and research data processing.
Library
Computerized database searches; document delivery; 6,000 books;
10,000 volumes of journals; 300 active journal subscriptions;
7,000 slides, videotapes, and other audiovisual materials. This
is a major international resource.
Animals
Macaca mulatta (about 1,000); M. arctoides (80); Callithrix
jacchus (235); Saguinus oedipus (10). The center maintains a
breeding colony that produces more than 130 rhesus infants a year
and is self-sufficient in its breeding programs.
Yerkes Regional Primate Research Center
Emory University
Atlanta, GA 30322
(404) 727-7707
FAX: (404) 727-0623
Center facilities include the main station on 25 acres of the
Emory University campus in Atlanta, and a 117-acre field station
for behavioral biology research in nearby Lawrenceville.
Center Director
Thomas R. Insel, M.D.
Principal Investigator
Charles R. Hatcher, M.D.
Vice President for Health Affairs
Emory University
Contact
Thomas R. Insel, M.D., (404) 727-7707
Harold M. McClure, D.V.M., associate director for scientific
programs, (404) 727-7742
Basic Research Mission
Neurobiology and vision, behavioral biology, pathobiology and
immunobiology, and reproductive biology.
Current Research
Neurobiology =
Neuroanatomical, neurophysiological, neuropsychophysical effects
of experimental treatment approaches for maximizing visual
development in infants after surgical removal of congenital
cataracts. Prevention and treatment of various visual disorders.
Development of intracorneal lens implants. Excimer laser for
ophthalmic surgery. Consequences of prenatal drug exposure on
behavioral and physical development. Effects of drugs on
respiration. Treatment for myopia. Neurohormonal regulation of
pituitary function and sexual maturation. Brain cell implants for
treatment of Parkinson's disease. Restoring limb movement after
spinal cord injury. Light- and electron-microscopic analysis of
the organization and maturation of the visual processing system
in the brain. Effects of aging on the primate nervous system.
Behavioral Biology
Physiological and behavioral concomitants of drugs of abuse.
Consequences of prenatal drug exposure on behavioral and physical
development. Effects of drugs on respiration. Treatment
strategies against chronic drug use. Biological, social, and
environmental factors that affect fertility and influence the
onset of puberty and reproductive activity in primate social
groups. Expression and control of aggression in primate social
groups. Sexual behavior and its regulation by hormones.
Psychobiological development of young primates. Vocalizations and
communication in primate social groups. Behavioral effects of
hormonal contraceptives. Social and reproductive characteristics
of pygmy chimpanzees. Effects of growth hormone on reproductive
maturation. The organizational role of steroid hormones in
behavior and development in nonhuman primates. Effects of social
stress on behavioral endocrine and immune systems. Behavorial
mechanisms of conflict resolution in monkeys and apes. =
Pathobiology and Immunobiology
Chimpanzee and monkey models for research on AIDS immunology and
virology, and development and testing of vaccines and drugs
against AIDS. Primate models for research on onchocerciasis,
schistosomiasis, malaria, artificial implanted teeth, prevention
and treatment of periodontal disease, treatment of vesicoureteral
reflux. Identification and development of primate models for
research on immunological disorders. Evaluation of naturally
occurring nonhuman primate diseases and pathology to identify
animal models for human diseases. Studies of the effects of
cytokines on immunohematopoietic regeneration. Studies of
thrombosis, antithrombotic drugs, graft material for carotid
artery surgery, and mechanisms of damage caused by extracorporeal
circulation. =
Reproductive Biology
Development of a nonhormonal fertility control method based on
cyclic changes in cervical mucus. GnRH agonist for male fertility
control. Sperm surface changes related to fertility. Adrenarche,
puberty, and reproductive cycles. Maturational role of neonatal
testosterone surge. Reproductive/sexual rehabilitation of
spinal-cord-injured human males. Behavioral effects of oral
contraceptives. Ape reproduction. Reproductive behavior and
physiology of gibbons. Conservation of endangered primate species
through artificial breeding, cryopreservation, and fertility
assessment research.
Resources Provided
To Outside Investigators
Research proposals may be submitted by investigators from other
institutions. The scientific value of the proposal,
appropriateness of the primate species, experimental design,
provisions for humane treatment of the animals, and
qualifications of the researcher are evaluated by the Yerkes
Research Advisory Committee, whose recommendations are reviewed
by the center director. All proposals are reviewed by the Primate
Subcommittee of the Emory Institutional Animal Care and Use
Committee. Services available to outside investigators at
approved rates include:
Specimens
Tissue and organ specimens and body fluids from great apes and
monkeys are provided when available. Preparation and shipping
costs are paid by recipients.
Veterinary Medicine
Preventive medicine. Care and monitoring of research primates on
24-hour basis. Experimental surgery. Preoperative evaluation and
preparation. Anesthesia and analgesia. Postoperative care.
Collection of biological samples. Consultation on protocol design
and instrumentation.
Pathology
Clinical laboratory service, necropsy, histopathology, FACscan
analyses, and diagnostic electron microscopy. Specimens of
fluids, tissues, organs, and other biological materials are
available at approved rates.
Radioimmunoassays
Assays for 18 steroid hormones, 24 protein hormones, and 7 other
biological products.
Transmission and Scanning Electron Microscopy (SEM) and X-ray
Microanalysis =
The SEM facility provides conventional SEM with x-ray
microanalysis and high-resolution SEM of delicate specimens.
Bioelectronics, Instrumentation, and General Shop
Research instrumentation development; bioelectronics; computer
facilities and services. Fabrication, modification, maintenance,
and repair of test equipment and instrumentation. Specialized
caging and components.
Information Services
Includes public and media information, photography, and library
services.
=
Animals
Macaca mulatta, M. nemestrina, M. arctoides, M. fascicularis,
Cercocebus atys, Papio spp., Saimiri sciureus, Pan troglodytes,
Pan paniscus, Pongo pygmaeus, Gorilla gorilla, Hylobates lar.
=
University of Texas at Bastrop
M. D. Anderson Science Park
Route 2, Box 151-B1
Bastrop, TX 78602
(512) 321-3991
FAX: (512) 332-5208
Principal Investigator
Michale E. Keeling, D.V.M.
Professor and Chairman =
Veterinary Sciences Department =
=
Contact
Michale E. Keeling, D.V.M., (512) 321-3991
D. Rick Lee, D.V.M., (512) 321-3991
Research Emphases
Basic Objective
To produce chimpanzees that are physically and behaviorally
capable of reproduction for retention either as breeders or as
seed breeding stock for other production colonies; animals in
excess of these needs are available for critical biomedical
research and testing. To conduct relevant research projects of
benefit to chimpanzee health, productivity, and well-being. To
develop procedures for artificial insemination and embryo
collection and transfer.
Current Research
Developing and improving techniques of behavioral rehabilitation.
Behavioral investigation of factors influencing the production of
successful breeders and improvements in the husbandry and
well-being of chimpanzees. Collaborative programs in genetic
management.
=
Resources Provided
A demographically balanced group of 107 physically and
behaviorally healthy chimpanzees to establish a self-propagating
breeding population of chimpanzees to meet current and future
research and testing needs in the United States. The breeding
colony is housed in eight 4,500-square-feet outdoor corrals in
multiple-male, family groups.
New Technology/Procedures/Services
Semiannual, 4-day training workshop.
Animals =
Chimpanzees in excess of replacement breeder needs are available
to investigators supported by NIH grants and contracts.
Biological Materials =
Tissues and body fluids are available when coordinated with
preventive health procedures.
Other Services
The breeding colony is available for collaborative, noninvasive,
nonintrusive projects that do not disrupt the breeding
objectives. Complete facilities and services are available for
visiting scientists.
Core Staff
M. Keeling, D.V.M.; D. Rick Lee, D.V.M.; P. Alford, D.V.M.; M.
Bloomsmith, Ph.D.; and T. Beck, B.S.
Collaborative Staff
Jo Fritz; William H. Stone, Ph.D.
Collaborative Institutions
Primate Foundation of Arizona, Mesa, AZ 85277-0027, (602)
832-3780; Trinity University, Department of Biology, San Antonio,
TX 78212, (512) 736-8347. =
Primate Foundation of Arizona
P. O. Box 20027
Mesa, AZ 85277-0027
(602) 832-3780
FAX: (602) 830-7039
Principal Investigator
Jo Fritz
Director
Contact
Jo Fritz
Research Emphases
Basic Objective
To produce behaviorally normal chimpanzees as future breeders,
and to conduct behavioral research and research to improve
captive management of chimpanzees.
Current Research =
Mother/infant behaviors, social development, physiological growth
and development, environmental enrichment.
Resources Provided
To Outside Investigators, Collaborating Scientists, and Graduate
Students
Those wishing to conduct research at this facility must have
their projects reviewed and approved by the director and the
institutional animal care and use committee. The colony is
available for research activities that do not interfere with the
primary mission of this program. =
New Technology/Procedures/Services
Quarterly publication of The Newsletter, devoted to information
and reports on chimpanzees (Pan troglodytes).
Animals
Approximately 80 chimpanzees of varying ages. Social group
housing.
Chimpanzee Breeding and Research Colony
Yerkes Regional Primate Research Center
Emory University
Atlanta, GA 30322
(404) 727-7756
FAX: (404) 727-7845
Principal Investigators
R. Brent Swenson, D.V.M.
Kim A. Bard, Ph.D.
Kenneth G. Gould, Ph.D., M.R.C.V.S.
Contact =
R. Brent Swenson, D.V.M.
Research Emphases
Basic Objective =
To establish a self-sustaining population of Pan troglodytes in
cooperation with similar NIH-funded projects; to ensure
availability of physically and behaviorally normal chimpanzees
for research and testing.
Current Research =
Investigation of infant developmental characteristics =
that predict future behavioral and reproductive competence;
investigation of techniques for early detection of impending
parturition.
=
Resources Provided
To Outside Investigators
Collaborative studies that do not interfere with the primary
goals of the project will be considered. Such projects must be
reviewed by the Yerkes center resources committee and approved by
the center director.
Specimens
Tissues and body fluids may be obtained at the time of routine
health examinations in this breeding colony of 90 Pan
troglodytes. Cost estimates for collection, packaging, and
shipping are available on request.
Animals
Limited numbers of animals in excess of the needs of the project
may be available for research; priority is given to NIH-sponsored
projects.
Chimpanzee Breeding and Research Colony
University of Southwestern Louisiana
New Iberia Research Center
100 Avenue D
New Iberia, LA 70560
(318) 365-2411
FAX: (318) 373-0057
=
Principal Investigator
William E. Greer, D.V.M.
Contact
William E. Greer, D.V.M.
T. Jeffrey Rowell, D.V.M.
Research Emphases
Basic Research Mission
To produce colony-bred primate species and to conduct research in
primate reproduction, physiology, behavior, and colony
management.
Resources Provided
To Outside Investigators
Animals
Chimpanzees of varying ages are available for assignment
primarily to investigators supported by NIH grants and contracts.
Other primate species are maintained in breeder groups for sale
or lease assignment.
To Collaborating Scientists and Graduate Students
Those wishing to conduct research at this breeding facility must
have their projects reviewed and approved by the interagency
animal model committee, and both the sponsor and host
institutional animal care and use committees. The breeding
colonies are available for research activities that do not
interfere with the primary mission of this program.
Animals
Approximately 300 chimpanzees; 3,500 animals in 12 Old World
species; 500 animals in 6 New World species; and other laboratory
and domestic animal species.
Chimpanzee Breeding and Research Colony =
The Coulston Foundation
P.O. Box 1027
Holloman Air Force Base, NM 88330-1027
(505) 479-9220
FAX: (505) 479-4103
Principal Investigator
Patrice Frost, D.V.M. =
Contact =
Patrice Frost, D.V.M.
Research Emphases
Basic Research Mission
Vaccine development and infectious disease studies, especially
retrovirology and hepatitis, in chimpanzees and macaques. Studies
of the efficacy and safety of potential new pharmaceuticals,
including routine and special toxicology, metabolism,
pharmacokinetics, residue, and immunogenicity studies. Research
in primate reproduction. Staff members include medical,
scientific and technical career specialists in reproductive
biology, animal husbandry, physiology, virology, immunology,
toxicology, comparative pathology and medical primatology.
Resources Provided
Collaborative research and gross, microscopic, and clinical
pathology services are available. Radioimmunoassay, analytical
chemistry, bacteriology, virology (P3), and immunology research
services are also available.
Animals =
The colony consists of 1,363 macaques and 325 chimpanzees. The
chimpanzee breeding colony includes 85 breeding and young
chimpanzees. Half of the offspring are reserved for future
breeding; the others are available for collaborative research.
The breeding animals may also be used for limited research that
does not interfere with the breeding mission. A detailed protocol
is required for review.
Applied Research for Improving the Behavioral Management of
Captive Chimpanzees
University of Texas
M. D. Anderson Science Park
Route 2, Box 151-B1
Bastrop, TX 78602
(512) 321-3991
FAX: (512) 332-5208
Principal Investigator
Mollie A. Bloomsmith, Ph.D.
Assistant Professor of Experimental Psychology
Contact =
Mollie A. Bloomsmith, Ph.D.
E-mail: an83119@mdacc.mda.uth.tmc.edu
Research Emphases
Basic Research Mission
This behavioral research program is designed to improve the care
and management of captive chimpanzees. This program is a
collaborative effort of the M.D. Anderson Center and the Primate
Foundation of Arizona. Studies identify factors that influence
the production of successful breeders from captive-born animals,
identify improvements in husbandry, and determine methods that
allow more precise predictions of and promote productivity in
captive chimpanzee populations.
=
Resources Provided
To Collaborating Scientists and Graduate Students
Individuals interested in collaborative studies must provide a
protocol for approval by the principal investigator and the
appropriate institutional animal care and use committees.
Genetics Typing Laboratory for Chimpanzees
Department of Biology
Trinity University
715 Stadium Drive =
San Antonio, TX 78212-7200
(210) 736-8347 or 736-8216
FAX: (210) 736-7229
Principal Investigator
William H. Stone, Ph.D.
Contact =
William H. Stone, Ph.D.
E-mail: wstone@trinity.edu
John Ely, Ph.D.
E-mail: jely@trinity.edu.
Susan L. Kohler, B.S.
Research Emphases
Basic Research Mission
To serve as a research resource for genetic typing of chimpanzees
(Pan troglodytes). DNA typing and biochemical markers are used
for paternity ascertainment in corroboration in multimale
breeding groups and are essential for pedigree reconstruction.
These genetic markers are used to corroborate pedigrees known
from housing records, to quantify genetic variability, and to
provide data for population genetic analyses. Our techniques
allow for the control of inbreeding, the maintenance of genetic
variability within small captive populations, and national mating
plans. The genetic data can be used in the design of specific
research protocols. Current research involves the identification
of unlinked genetic markers in the chimpanzee, such as
minisatellites, that can be used in the polymerase chain reaction
(PCR) for genetic typing.
Resources Provided =
To Outside Investigators
New Technology/Procedures/Services =
PCR using minisatellite dinucleotide repeats.
Animals =
DNA and biochemical typing of chimpanzees and other great apes.
To Collaborating Scientists and Graduate Students
Collaborator scientists or graduate students must provide DNA
samples for typing, typically as 10 to 20 mL uncoagulated whole
blood samples shipped overnight to our lab. Pricing is negotiable
depending on collaborator's resources. Acknowledgment must be
given in all publications, and two reprints donated. DNA typing
and biochemical genetic markers for paternity determination and
corroboration; genotyping and quantification of genetic
variability using DNA markers, PCR, isozymes and transferrins,
pedigree analysis, arranged mating and other aspects of genetic
management.
Animals =
Chimpanzees and other great apes.
Captive Population Dataset Assembly and Tracking, Analysis, and
Modeling
International Species Information System (ISIS)
12101 Johnny Cake Ridge Road
Apple Valley, MN 55124-8151
(612) 431-9295
FAX: (612) 432-2757
BBS: (612) 432-9292
Principal Investigator
Nathan R. Flesness, B.S.
Contact =
Nathan R. Flesness, B.S.
E-mail: isis@maroon.tc.umn.edu
Rick Lukens, M.S. (612) 431-9341
Research Emphases
Basic Research Mission
To contribute to the preservation of biotic diversity by
providing global specimen and species catalogs and auxiliary
information services; to support long-term collective species
conservation and preservation programs.
Resources Provided
To Outside Investigators =
ISIS is an information center designed to provide population data
collection, analysis, and management expertise in support of the
National Chimpanzee Breeding Plan. Gross pooled animal inventory
and specific chimpanzee information is provided to the Chimpanzee
Breeding and Research Program.
To Collaborating Scientists and Graduate Students
Opportunities exist for collaborative investigations using
assembled studbook dataset for chimpanzees, and sophisticated
software for demographic and genetic analysis. No animals are
held or otherwise retained by ISIS.
Specific-Pathogen-Free Macaques
Laboratory Animal Breeders and Services (LABS)
Highway 17A at Old Sheldon Church Road
P.O. Box 557
Yemassee, SC 29945
(803) 589-5190 or 589-5390
FAX: (803) 589-5290
=
Principal Investigator
David M. Taub, Ph.D.
President =
Contact =
David M. Taub, Ph.D.
Patrick Mehlman, Ph.D.
Research Emphases
Basic Research Mission
To produce physically and behaviorally normal rhesus and
pig-tailed monkeys free of Herpes simiae, SRV, SIV and STLV-1
viruses; to establish a self-sufficient breeding colony capable
of producing several hundred progeny each year for AIDS and
AIDS-related research; to conduct relevant research aimed at
efficient colony management, health, productivity and behavioral
well-being.
=
Resources Provided
To Outside Investigators
A demographically balanced breeding colony of
specific-pathogen-free (SPF) rhesus and pig-tailed macaques, all
antibody-negative for Herpes simiae, SRV, SIV, and STLV-1.
Composed of physically healthy and behaviorally normal animals,
the breeding colony of about 500 animals is housed in 12 outdoor
corrals, each composed of multiple male/female social units.
Animals =
Antibody-negative progeny are available to Public Health
Service-supported investigators for AIDS and AIDS-related
research.
To Collaborating Scientists and Graduate Students
Those wishing to conduct research at this breeding facility must
have their projects reviewed and approved by both the sponsor and
host institutional animal care and use committees, and receive
approval from the project officer of the sponsoring federal
agency. The breeding colony is available for multidisciplinary
collaborative, noninvasive, nonintrusive projects that are
compatible with the breeding objectives of the program. Complete
facilities and services are available for collaborative and
visiting scientists, including on-site housing.
Animals =
The breeding colony of about 500 animals is made up of 12
breeding units housed in outdoor corrals approximately one-third
acre in size. Groups are normal in structure, with multiple males
and females plus immature offspring.
Specific-Pathogen-Free Macaques
Veterinary Sciences Department
University of Texas at Bastrop
M.D. Anderson Science Park
Route 2, Box 151-B1
Bastrop, TX 78602
(512) 321-3991
FAX: (512) 321-1423
Principal Investigator
Michale E. Keeling, D.V.M.
Professor and Chair
Contact =
Michale E. Keeling, D.V.M. =
Stephanie J. Buchl, D.V.M.
Research Emphases
Basic Research Mission
Establish a production resource of rhesus monkeys free of
retrovirus and herpes B virus (SPF) to be used in AIDS-related
research. The resource must be a healthy, productive, socially
enriched SPF breeding colony that will help satisfy long-range
national research and testing requirements. Validate a derivation
strategy for converting a conventional breeding colony into an
SPF breeding colony. Validate enrichment strategies for
maintaining psychological health in captive populations of
monkeys.
Resources Provided
To Outside Investigators
New Technology/Procedures/Services =
Semiannual, 4-day training workshop.
Animals =
After a 30-day first-right-of-refusal to NIH investigators,
psychosocially competent rhesus monkeys, free of retroviruses and
herpes B virus, are available to other investigators for AIDS and
AIDS-related biomedical research.
To Collaborating Scientists and Graduate Students
Individuals interested in collaborative research or training
programs must provide the principal investigator a written
proposal approved by the sponsoring institution's animal care and
use committee. The colony is available for collaborative,
noninvasive, nonintrusive investigations. Collaborative research
cannot disrupt the breeding and SPF derivation strategy.
Animals =
SPF rhesus monkeys in excess of the needs of NIH investigators
are available for purchase.
Core Staff
M. Keeling, D.V.M.; S. Buchl, D.V.M.
Collaborative Staff
M. Bloomsmith, Ph.D.; S. Schapiro, Ph.D.; J. Hilliard, Ph.D.; N.
Lerche, D.V.M., M.P.V.M.; W. Stone, Ph.D. =
Specific-Pathogen-Free Rhesus Monkeys
Division of Veterinary Resources (R289)
University of Miami School of Medicine
1600 N. W. 10th Avenue
Miami, FL 33136
(305) 547-6802
FAX: (305) 547-5739
=
Principal Investigator
Joseph L. Wagner, D.V.M.
Contact =
Joseph L. Wagner, D.V.M.
Research Emphases
Basic Research Mission
To establish and maintain a breeding colony of rhesus monkeys
free of Herpesvirus simiae (B virus) and specific simian
retroviruses to support research on AIDS. =
Resources Provided
To Outside Investigators
New Technology/Procedures/Services =
Projects must be reviewed by the institutional animal care and
use committees of both the sponsor and host institutions. Body
fluids may be obtained at the time of routine health
examinations. Tissues may be obtained during routine postmortem
examinations. Cost estimates for collection, packaging, and
shipping are available upon request. The breeding colony is
available for research activities that do not interfere with the
primary mission of the project. The University of Miami is a
CDC-approved nonhuman primate quarantine facility and Miami
International Airport is a USDA Port of Entry. We have the
capacity to hold up to 150 animals for the required holding
period. Special arrangements can be made for treatment, sample
collecting, etc., by calling the principal investigator. Outside
and indoor facilities are available for housing nonhuman
primates. At this time, only South American species are being
considered for this space use. Special arrangements can be made
for other species.
Animals =
Animals are available for biomedical research. Priority is given
to NIH-sponsored projects on AIDS-related research.
To Collaborating Scientists and Graduate Students
Animals =
300 adult breeding Macaca mulatta.
Specific-Pathogen-Free Rhesus Monkeys
New England Regional Primate Research Center
1 Pine Hill Drive
Southborough, MA 01772
(508) 624-8095
FAX: (508) 624-8190
Principal Investigator
David Lee-Parritz, D.V.M. =
Contact =
David Lee-Parritz, D.V.M.
Research Emphases
Basic Research Mission
This SPF breeding program consists of 300 Indian-origin rhesus
monkeys that are free of Herpesvirus simiae, simian
immunodeficiency virus, simian T-lymphotropic virus 1, and type D
retrovirus. Animals are maintained in a closed colony. Frequent
antibody screening is performed to assure SPF status. Surplus
juvenile males and retired breeders are assigned to approved AIDS
research projects. Priority is given to Public Health
Service-sponsored projects.
Resources Provided
To Outside Investigators
Animals
SPF rhesus monkeys and blood samples for sale as available to
qualified outside investigators, subject to the approval of the
center director.
To Collaborating Scientists
Scientists wishing to conduct research at the center must have
projects reviewed and approved by the center director, the
executive committee, and the institutional animal care and use
committee. A brochure explaining the collaborative research
program is available from the center office. The center's
services are available to collaborating scientists. Some services
are provided without charge, some on a fee basis. Services
include veterinary clinical services, BL3 biocontainment
facility, necropsies, clinical pathology and hematology, electron
microscopy, and isolation of viral and bacterial agents.
Animals =
Animals and blood samples for sale as available to qualified
collaborating scientists, subject to the approval of the center
director.
Specific-Pathogen-Free Rhesus Monkeys
Michigan Department of Public Health
Bureau of Laboratories and Epidemiological Services
3500 N. Logan
P. O. Box 30035
Lansing, MI 48909
(517) 335-8145
FAX: (517) 335-9486
Principal Investigator
Barbara A. Kintner, D.V.M.
Contact =
Barbara A. Kintner, D.V.M.
Research Emphases
Basic Research Mission
SPF rhesus monkeys are reared in breeding harems. Replacement
breeders are generated from the existing colony, and all monkeys
are housed in groups to foster normal social development. Because
of their SPF status, the monkeys that are available for sale are
ideal for use in AIDS research.
Resources Provided
To Outside Investigators
Animals =
Rhesus monkeys free of retroviruses and B virus, negative for
tuberculosis, and of known ancestry.
To Collaborating Scientists and Graduate Students
Animals =
Rhesus monkeys free of retroviruses and B virus, negative for
tuberculosis, and of known ancestry.
Specific-Pathogen-Free Macaque Monkeys
Texas Primate Center
HRP, Inc.
P. O. Box 549
Alice, TX 78333
(512) 664-4984
Center Director and Principal Investigator
Stephen L. Pearson, D.V.M.
Contact =
Stephen L. Pearson, D.V.M.
Research Emphases
Basic Research Mission
By repeated testing (serology and culture) to establish a rhesus
and pig-tailed monkey colony free from viral pathogens that would
interfere with using the offspring produced for critical AIDS
research studies.
Resources Provided
Breeding colony of rhesus and pig-tailed monkeys free from
infection with the Herpes simiae, SIV, SRV, and STLV-1 viruses.
To Outside Investigators
Priority is given to Public Health Service-funded AIDS or
AIDS-related research projects.
New Technology/Procedures/Services =
Priority is given to Public Health Service-funded AIDS or
AIDS-related research projects. A new, small breeding colony of
Macaca nemestrina is in the formative stage. After multiple viral
screens, 20 to 30 of the 1993 offspring are available.
Animals
Two-year-old offspring are available from the SPF rhesus
breeding colony.
To Collaborating Scientists and Graduate Students
Animals =
In 1994 and subsequent years approximately 100 of the 18- to
24-month-old SPF rhesus animals are available for sale each year.
Simian Retrovirus Reference Laboratory
California Regional Primate Research Center
University of California, Davis
Davis, CA 95616
(916) 752-6490
FAX: (916) 752-2880
E-mail: nwlerche@ucdavis.edu
Principal Investigator
Nicholas W. Lerche, D.V.M., M.P.V.M.
Contact
Nicholas W. Lerche, D.V.M., M.P.V.M.
Ann Rosenthal, M.S., laboratory manager, (916) 752-4818 or
752-8242;
FAX: (916) 752-4816; or =
E-mail:szrosent@hamlet.ucdavis.edu.
Research Emphases
Basic Objectives
To improve and maintain the quality of nonhuman primates used in
biomedical research through the diagnosis and control of
exogenous simian retroviruses; to develop improved methods for
the diagnosis of simian retrovirus infections; and to develop and
maintain a reference repository of simian retrovirus antigens and
antisera.
Current Research
Application of serological and virological methods to the control
and eradication of exogenous simian retroviruses in captive
populations, and the establishment and maintenance of
retrovirus-SPF breeding colonies of nonhuman primates.
Investigations of the epidemiology and pathogenesis of simian
retroviruses in natural and aberrant host species, and the
development of nonhuman primate models for human retroviral
diseases.
Resources Provided
New Technology/Procedures/Services =
To maintain the resource, cost reimbursement is requested for
procedures performed to identify potential retroviral infections
in nonhuman primates. Polymerase chain reaction (PCR) for
detection of simian immunodeficiency virus (SIV) or simian
retrovirus D (SRV-D) in nonhuman primate tissues.
Diagnostic Services
Serological and virological testing of nonhuman primates for the
exogenous simian retroviruses SIV; simian T-lymphotropic virus
(STLV); and SRV-D. Diagnostic resources are primarily for support
of animals used in biomedical research, but services are also
provided to zoological collections by arrangement. Laboratory
services are also available for collaborative or contractual
experimental research projects.
Epidemiology Services
In addition to diagnostic resources, epidemiologic services are
available to assist in the development and implementation of
strategies for control and elimination of simian retrovirus
infections in captive populations, and in establishing and
maintaining breeding colonies of nonhuman primates that are free
of specific retrovirus pathogens. A nonhuman primate serum bank
is also maintained and is available for use in collaborative
research projects by arrangement.
B-Virus Diagnostic Resource and Research Laboratory
Department of Virology and Immunology
Southwest Foundation for Biomedical Research
7620 N. W. Loop 410 (for deliveries)
P. O. Box 28147 (for mail)
San Antonio, TX 78228
(210) 673-3269 or 674-1410
FAX: (210) 673-3529
Principal Investigators
Julia K. Hilliard, Ph.D.
Radmila Mirkovic, M.D.
Contact
Julia K. Hilliard, Ph.D., E-mail: juliah@darwin.sfbr.org
Radmila Mirkovic, M.D. Compuserve: 713 70,3464
Martin Wildes, laboratory manager, (210) 673-3269 or (210)
674-1410. Digital pager: 1 (800) 443-7243; enter access code
011422 from a touchtone phone, then at tone enter number to which
call should be returned.
Research Emphases
Basic Objectives =
To identify B-virus infections and study basic pathogenesis
mechanisms of this and other neurotropic herpesviruses; control
and prevention strategies of B-virus infections. All samples
evaluated by the resource can be used in ongoing research
studies.
Current Research
Assessment of evolutionary conservation among alpha-herpesviruses
by biochemical, immunological, and molecular biological
approaches; development of recombinant reagents; identification
of effective antiviral strategies and design of putative
vaccines; elucidation of host-virus interactions during
pathogenesis; collaborative identification/exploration of
putative alpha-herpesviruses not previously described.
=
Resources Provided
Diagnostic Services =
This laboratory resource is designed to provide rapid virological
and serological analyses to identify Herpesvirus simiae (B virus)
infections in humans and nonhuman primates, particularly
macaques. Virological analyses are performed by virus isolation,
polypeptide analysis, DNA restriction endonuclease analyses, and
experimental PCR (polymerase chain reaction). Serological
analyses include ELISA, competition ELISA, and Western blot
analyses. The laboratory also provides telephone and mail
information to requestors seeking assistance for identifying
infections, and/or CDC-derived information for handling human or
macaque cases of B-virus infection. Staff are available for
collaboration in investigating cases of B-virus infection in
humans and nonhuman primates. Resource staff perform all
diagnostic services adjacent to the herpesvirus research
laboratory of the principal investigator. This proximity permits
consultation and additional assistance between staff members when
required.
Other Services
Specialized (BCL-4) laboratory biocontainment facilities,
investigation of new animal models of herpesvirus disease,
antiviral testing, epidemiological analyses of alpha-herpesvirus
outbreaks, necropsy and autopsy assistance for virological
analyses of B-virus infections, assistance in developing SPF
primate colonies.
Fees =
Cost reimbursement for procedures performed to identify potential
B-virus infections in humans and nonhuman primates is requested
to maintain the resource.
Applied Research for Improving the Behavioral Management of the
Captive Rhesus Monkey
University of Texas
M.D. Anderson Science Park
Route 2, Box 151-B1
Bastrop, TX 78602
(512) 321-3991
FAX: (512) 332-5208
Principal Investigator & Contact
Mollie A. Bloomsmith, Ph.D.
E-mail: an83119@mdacc.mda.uth.tmc.edu
Research Emphases
Basic Research Mission
This behavioral research program is designed to improve the
management of captive rhesus monkeys and to maximize the
behavioral potential of the SPF monkeys derived from our colony.
Environmental enrichment techniques for singly and group-housed
rhesus have been devised and evaluation continues.
Effects of the social restriction involved in the SPF derivation
strategy on breeding and parenting skills are being measured.
Relationships between environmental enrichment, hormonal measures
of stress, behavioral indices of stress, and virus status have
been analyzed statistically.
=
Resources Provided
To Collaborating Scientists and Graduate Students
Individuals interested in collaborative studies must provide a
protocol for approval by the principal investigator and the
appropriate institutional animal care and use committees.
Genetics Typing Laboratory
California Regional Primate Research Center and
Department of Anthropology
University of California, Davis
Davis, CA 95616
(916) 752-6343
FAX: (916) 752-8885
Principal Investigator
David Glenn Smith, Ph.D.
Contact =
David Glenn Smith, Ph.D.
Phillip A. Morin, Ph.D., (916) 752-5598; FAX: (916) 752-8885; =
E-mail: fzpmorin@bullwinkle.ucdavis.edu.
Research Emphases
Basic Research Mission
Identify and characterize previously unknown polymorphisms, study
the effectiveness of alternative genetic management strategies
and the effect of demographic factors on the population/genetic
structure of captive groups, and identify marker loci for genes
that influence susceptibility to retroviral and B-virus
infection.
Resources Provided
To Collaborating Scientists and Graduate Students
New Technology/Procedures/Services
All principal investigators of NIH-supported SPF breeding
programs or their designees. Conduct genetic fingerprinting
analysis and genetic marker analysis on rhesus macaques (Macaca
mulatta), crab-eating macaques (M. fascicularis), and pig-tailed
macaques (M. nemestrina), and other species in SPF colonies;
identify paternity, calculate kinship and inbreeding
coefficients, estimate parameters of genetic diversity, genetic
subdivision, and founder representation within the colony; and
collaborate with principal investigators on colony management
strategies and on research involving those data. Typing of
microsatellite DNA polymorphisms; we provide public access to
information on new genetic polymorphisms via the Gopher
electronic communication network. Direct the Gopher =
client to
gopher.ucdavis.edu
Research Support
Primate Research Center
Primate Genetics Markers
The Caribbean Primate Research Center (CPRC) has three
facilities: A free-ranging island colony of rhesus monkeys on
Cayo Santiago; 410 acres on Sabana Seca housing three Old-World
species; and the CPRC Museum on the Medical Sciences Campus in
San Juan with 2,500 complete skeletons from 10 primate species. =
=
University of Puerto Rico =
Medical Sciences Campus
P. O. Box 1053
Sabana Seca, PR 00952-1053
(809) 784-6619 or (809) 784-0322
FAX: (809) 795-6700
Principal Investigator and Contact
Matthew J. Kessler, D.V.M.
Research Emphases
Cayo Santiago
Short- and long-term studies of social and sexual behavior,
population genetics, demography, reproductive biology, functional
morphological and spontaneous diseases (arthritis, adult-onset
macular degeneration, diabetes, obesity, hypertension) and
parasitoses of rhesus monkeys maintained under seminatural
conditions. Colony size: 1,000.
Sabana Seca
Biomedical research on spontaneous diseases, reproductive
biology, social behavior, and husbandry of Old-World (rhesus and
pigtail macaques, patas) monkeys maintained under a variety of
housing configurations (individual cages, pens, enclosures, and
large [1 to 2 acre] corrals). Colony size: 750.
CPRC Museum
Anthropological and biomedical osteological research on 2,500
complete skeletons from 10 species of nonhuman primates including
more than 1,000 from Cayo Santiago rhesus monkeys of known
identity, age, sex, matriline, and parity; and 175 skeletons from
patas monkeys.
=
Resources Provided
To Collaborating Scientists
The Caribbean Primate Research Center welcomes collaborative
research with established behavioral and biomedical investigators
and encourages the use of its animal and osteological resources
for dissertation research. Investigators are charged modest use
fees for access to the animals, skeletal collection, computerized
database, and office space, and for housing units located near
Cayo Santiago and at Sabana Seca. All proposals are subjected to
rigorous review and are judged on scientific merit, feasibility,
and potential overlap with ongoing studies. Protocols must also
be approved by the institutional animal care and use committee.
Enhancing the Mouse Resource: Recombinant Inbred Strains
The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609-0800
(207) 288-3371
FAX: (207) 288-5172
Principal Investigator
Beverly J. Paigen, Ph.D.
Contact
For mice: The Jackson Laboratory, (800) 288-MICE. =
For database information: Janan Eppig, Ph.D. (207) 288-3371; =
FAX: (207) 288-5079; E-mail: jte@aretha.jax.org. =
For other information: Beverly Paigen, Ph.D. =
(207) 288-3371 x 1383; FAX: (207) 288-5172; =
E-mail: bjp@aretha.jax.org. =
Research Emphases
Basic Objectives
Recombinant inbred strains are derived by systematic inbreeding
from the cross of two pre-existing progenitor strains. Sets of
recombinant inbred strains are valuable for testing mendelian
inheritance, for linkage analysis, for detecting (or excluding)
linkage, for estimating recombination frequency, for determining
gene order, for discovering or analyzing pleiotropic effects of
individual genes, or for defining genotype-phenotype
relationships. The chief advantage of recombinant inbred strains
for linkage analysis derives from the cumulative nature of the
recombinant inbred data. Newly defined strain distribution
patterns can be compared with previously determined strain
distribution patterns to search for similarities or identities
that would indicate or suggest linkage.
Current Research
Adding polymorphic markers to the AXB, BXA recombinant inbred
set.
Resources Provided
To Collaborating Scientists
New Technology/Procedures/Services =
Database on Map Manager for all recombinant inbred strain sets. =
Genetics Laboratory for Typing Nonhuman Primates
Trinity University
715 Stadium Drive
San Antonio, TX 78212-7200
(210) 736-8347 or 736-8216
FAX: (210) 736-7229
Principal Investigator
William H. Stone, Ph.D.
Contact =
William H. Stone, Ph.D. E-mail: wstone@trinity.edu
John J. Ely, Ph.D.
Susan L. Kohler, B.S.
Research Emphases
Basic Objectives =
To serve as a research resource for genetic typing of nonhuman
primates of various Old World and New World species. The genetic
markers are essential tools for maintaining accurate pedigree
records by resolving disputed parentage and monitoring pedigrees,
minimizing inbreeding and other factors leading to the loss of
genetic variability. They are crucial to genetic management of
primate colonies and can be used to estimate genetic distances
and other population genetic parameters useful for management and
for more specific research protocols.
Current Research
Our aim is to define four or five genetic markers in commonly
used nonhuman primates species, such as rhesus monkeys. We
concentrate in three major areas the serum protein Tf, isozymes,
and DNA typing. Our research concerns major areas in which these
genetic markers play a significant role: population genetics,
markers for other traits such as major genes for polygenic
traits, maintenance of genetic variation, monitoring breeding (by
identifying individuals and parentage), controlling inbreeding,
and developing breeding programs.
=
Resources Provided
Diagnostic Services
We can provide a genetic profile consisting of several different
genetic systems, plus DNA fingerprints, which together can define
an almost unlimited number of different phenotypes.
Procedures include Southern blotting and PCR using
minisatellites; tests for serum proteins, including the
transferrin system and the complement (C3) system; isozyme typing
for polymorphic erythrocyte enzymes including phosphogluconate
dehydrogenase (PGD), glucose phosphate isomerase (GPI), carbonic
anhydrase (CA2), and phosphoglucomutase (PGM1); and DNA typing
using single locus tandem repeat markers at four or five loci.
Most typed loci are highly variable, making this technique
extremely useful for parentage determination and for research
strategies.
Mouse Mutant Gene Resource
The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609-1500
(207) 288-3371
FAX: (207) 288-8982
Principal Investigator
Muriel T. Davisson, Ph.D.
Director of Genetic Resources
Contact =
Muriel T. Davisson, Ph.D., x 1340
Kenneth R. Johnson, Ph.D., x 1422
Eva M. Eicher, Ph.D., x 1243
=
Research Emphases
Basic Objectives =
To discover and characterize new mouse models of human inherited
conditions; to maintain as breeding pairs and preserve as frozen
embryos new and established mouse mutations and chromosomal
aberrations; to develop genetically suitable stocks of new and
established mouse mutations for use in biomedical research; and
to make these mutant stocks available to interested investigators
in the scientific community.
Current Research
Discover and develop new spontaneous mouse mutations into new
models for a variety of different kinds of inherited human
diseases. Physiologic, pathologic, and genetic analysis of new
recessive mutations affecting the kidney, central and peripheral
nervous systems, muscle cells, embryological development and
reproduction, and skeletal development mutations.
=
Resources Provided
New Technology/Procedures/Services =
A method to efficiently map new spontaneous mouse mutations using
an inbred strain of Mus castaneus (CAST/Ei) and multilocus DNA
probes. The strain is available from our resource and we provide
information on the probes and the system (contact resource
supervisor Kenneth R. Johnson, Ph.D.). We encourage
collaborations with visiting investigators to screen our mutant
and wild-derived strains for specific condition, symptoms,
biochemical or physiological defects, etc. All mutations,
chromosome aberrations, and special strains can be ordered by
calling the Jackson Laboratory's Animal Resources, Production and
Distribution Department at (800) 432-MICE. A nominal fee to help
cover strain maintenance and shipping is charged for mice. For
more information about the resource, contact any of the three
investigators listed.
Animals =
Mice with specific mutant genes in various categories, including:
1. Growth development, reproduction, and endocrine: abnormal
spermatazoon heads (azh), blind sterile (bs) congenital goiter
(cog), curly tail (ct), Ames dwarf (df), disorganization (Ds),
dwarf-J (dwJ), dwarf grey (dwg), hypothyroid (hyt), sex reversal
(Sxr)(=3DTp(Y)1Ct), testicular feminization (Tfm), tubby (tub).
2. Neurological, neuromuscular and ocular: Ames waltzer (av3J),
aphakia (ak)*, ataxia (axJ)*, blind sterile (bs), claw paw (clp),
coloboma (Cm), dilute-neurological (dn), ducky (du), gyro (Gy),
hotfoot-4J (ho4J), jittery (ji), lurcher (Lc), lethargic (lh),
myotonia (adrmto), myotonia-2J (adrmto-2J), motor neuron
degeneration (mnd), nuclear cataract (nuc)*, ocular retardation-J
(orJ)*, ocular retardation-2J (or2J), oscillator (spdot),
polysyndactylism (Ps), quivering-3J (qv3J), rabbit (rb), retinal
degeneration (rd), Dickie's small eye (SeyDey), shaker-1 (sh1),
shambling (shm), sightless (Sig), spinal muscular atrophy (sma),
tumbler-2J (tb2J), tottering (tg), leaner (tgla), trembler-J
(TrJ), trembly-like (Tyl), wobbler lethal-2J (wl2J).
3. Skeletal: brachypodism-J (bpJ), belly spot and tail (Bst),
droopy ear-H (deH), head blebs (heb), meander tail-2J (mea2J),
oligosyndactylism (Os), polysyndactyly (Ps), pudgy (pu),
postaxial hemimelia (px)*, rachiterata (rh), rib vertebrae (rv),
curtailed (Tc), hairpin tail (Thp), brachyury-2J (T2J), tailkinks
(tk), tailshort variable (Tsv), ulnaless (Ul), vestigial tail
(vt).
4. Immunological and hair balding (bal), bare patches (Bpa), =
hairy ears (Eh), repeated epilation (Er), fur deficient (fd),
frizzy (fr), furless (fs), fuzzy (fz), greasy (Gs), harlequin
(Hq), nude (nu)*, plucked (pk), rex (Re), scant hair (sch),
sparse fur (spf), sparse fur-J (spfJ), abnormal skin and hair
(spfash), tabby (Ta), tufted (tf), velvet coat (Ve), waved-2
(wa-2).
5. Pigment white-bellied agouti (Aw), white-bellied agouti-J
(Aw-J), white-bellied agouti-15J (Aw-15J), beige-2J (bg2J)*,
belted-2J (bt2J), albino-9J (c9J)*, chinchilla (cch), Himalayan
(ch), chocolate (cht), cocoa (coa), cream (Crm), cream-J (CrmJ),
dominant brown (Uwdbr), dilute (d), dense-2J (d+2J), grizzled
(gr), grey coat (grc), leaden (ln), mahoganoid (md), mocha-2J
(mh2J), blotchy (Moblo), brindled (Mobr-J), microphthalmia white
(Miwh)*, tortoise shell (Moto), pewter (Mopew), pewter-2J =
(Mopew-2J), ochre (och), pink-eyed dilution (p), pink-eyed
dilution-J (pJ), ruby-eye 2J (ru-2J), sepia (sea), contrasted
(Slcon), slaty (slt), tabby (Ta), tabby-Bailey (TaBy), tabby-2J
(Ta2J), tabby-6J (Ta6J), taupe (tp)*, taupe-3J (tp3J), underwhite
(uw).
6. Kidney: Congenital progressive hydronephrosis (cph),
congenital polycystic kidney (cpk), kidney disease (kd).
7. Enzyme deficiences sparse fur (spf; mutation in ornithine
transcarbamylase-causing deficiency), spfash (allele of spf),
hypoxanthine phosphoribosyl transferase-targeted mutation
(Hprtb-m2).
Mice with chromosomal aberrations:
1. Inversions: In(X)1H.
2. Robertsonian chromosome: Rb(10.11)8Bnr*, Rb(1.3)1Bnr,
Rb(4.6)2Bnr, Rb(9.14)6Bnr.
3. Reciprocal X-autosomal translocations: T(X;4)37H, T(X;11)38H,
T(X;16)16H.
4. Insertional translocations: Is(In7;X)1Ct, Is(7;1)40H.
5. Reciprocal autosomal translocations: T(1;2)5Ca*, T(1;7)40H,
T(1;9)27H*, T(1;9)5Ei*, T(1;13)70H*, T(1;17)190Ca, T(2;3)24H*,
T(2;4)1Ca*, T(2;4)1Sn, T(2;4)13H*, T(2;6)7Ca*, T(2;8)26H*,
T(2;9)7Ei*, T(2;9)11H*, T(2;11)30H*, T(2;12)1Ei*, T(2;16)28H*,
T(2;17)6Ei*, T(3;4)5Rk*, T(3;12)30Rk*, T(4;8)36H*, T(5;8)3Rk*,
T(5;12)31H*, T(5;13)264Ca*, T(7;15)9H, T(7;18)50H, T(7;19)145H*,
T(8;16)17H*, T(9;17)10Ad*, T(9;17)138Ca, T(10;18)18H*,
T(10;13)199H*, T(11;13)3Ei*, T(11;19)42H*, T(12;17)4Rk,
T(13;17)2Ei*, T(16;17)43H*.
6. Monosomy: XO. =
=
7. Trisomy (segmental): Ts1Lws.
Y chromosome congenic strains: C57BL/6By-YCBy, C57BL/6By-yPL.
Several linkage testing stocks and inbred strains, including:
1. Wild-derived strains: CASA/Rk and CAST/Ei (Mus castaneus);
IS/CamRk, SF/CamEi, SK/CamEi (Skokholm); PERA/Ei (PERU-Atteck),
PERC/Ei (PERU-Coppock); MOLD/Rk, MOLF/Ei, and MOLG/Dn (Mus
molossinus); SPRET/Ei (Mus spretus); three pure Mus domesticus
stocks (TIRANO/Ei, ZALENDE/Ei, Watkin Star Line B (WSB); Mus
hortulanus (PANCEVO), Mus musculus (CZECH II), Mus
musculus/domesticus (SKIVE/Ei).
2. Congenics with enzyme variants: B6.CAST-Gpi-1a/Ei, C.B6-tc =
Hbbs, C57BL/6J-Pgk1a.
3. Strains with rare polymorphic variants: LDH2/Ei Ldh-2l,
IDH2/Ei Idh-2b, SOD1/Ei Sod-1l. =
4. Special inbred strains: YBR/Ei, BALB/cWtEi. =
Recombinant inbred strain set NXSM, a 17-member set.
*These stocks are available from the Frozen Embryo Repository.
There is a surcharge for embryo recovery in addition to the
regular cost of the mice.
Referral Center for Animal Models of Human Genetic Disease
School of Veterinary Medicine
University of Pennsylvania
3800 Spruce Street
Philadelphia, PA 19105
(215) 898-8880
FAX: (215) 898-9923
=
Principal Investigator
Donald F. Patterson, D.V.M., D.Sc.
Contact =
Donald A. Patterson, D.V.M., D.Sc.
For specific genetic diseases, see individual sections. =
Research Emphases
Basic Objectives =
To identify, characterize, evaluate, and disseminate animal
homologs of human genetic disease, particularly those that will
serve as useful models for research on the pathogenesis and
therapy of genetic diseases.
Current Research
Research projects involving established models include
pathogenesis and treatment of the mucopolysaccharidoses (MPS I
and MPS VI in the cat; MPS VII in the dog); pathogenesis of a
dominantly inherited defect in collagen fibrillogenesis in the
cat; pathogenesis of alpha-mannosidosis in the cat; and the
underlying biochemical defect in dominantly inherited porphyria
in the cat.
=
Recently newly discovered models under investigation include
X-linked severe combined immunodeficiency (XSCID) in the basset
hound; an autosomal recessive defect in the intestinal absorption
of vitamin B12 in the giant schnauzer; and glycogenosis type IV
(branching enzyme deficiency) in the cat.
=
Resources Provided
To Outside Investigators
Consultation and Diagnostic Services =
A primary objective of the referral center is to provide
consultation, certain diagnostic services, and preliminary
genetic studies to facilitate the discovery and preservation of
new and potentially useful animal models for human genetic
diseases. Emphasis is on models that occur in domestic animals.
Priority is given to studies of models that appear to offer the
most promising potential for investigating underlying mechanisms
and new approaches to therapy, including gene therapy. Services
available depend on preliminary consultation and evaluation of
the potential model by scientists at the referral center. These
general classes of genetic disease are emphasized:
Hereditary Metabolic Diseases =
Includes inborn errors of amino acid, organic acid, carbohydrate,
and glycosaminoglycan metabolism. Contact Dr. Urs Giger, =
(215) 898-8076, or Dr. Mark Haskins, (215) 898-8894.
Hereditary Defects in Sexual Development =
Includes male and female peudohermaphroditism, sex reversal, and
true hermaphroditism. Contact Dr. Donald F. Patterson, =
(215) 898-8880.
Hereditary Congenital Malformations =
Includes congenital heart disease and anomalies of other organ
systems. Particular emphasis given to malformation syndromes that
may be due to chromosomal anomalies or single major gene
mutation. Contact Dr. Donald F. Patterson, (215) 898-8880, or =
Dr. Mark Haskins, (215) 898-8894.
Hereditary Hematologic Diseases =
Includes inborn errors of erythrocyte metabolism, membrane
defects, and leukocyte defects resulting in immunodeficiencies.
Contact Dr. Urs Giger, (215) 898-8830.
If an affected animal is deemed a potentially new and useful
model after the initial consultation, these services are
available:
Clinical Examination
Usually arrangements for transporting the affected animal to the
center are the responsibility of the veterinarian or other
investigator who made the referral. Physical examinations and
routine diagnostic tests are performed. If an animal shows
sufficient promise as a disease model, the center pays shipping
charges. If the animal is owned by the client and the examination
is primarily in the interest of the owner, a reduced fee for
clinical services is charged to the owner.
Postmortem Examination
After initial consultation, the center provides instructions for
fixation. Examinations include gross and microscopic studies of
whole organs and tissues, electron microscopy and special
histochemical stains.
Metabolic Screening
This consists of a series of chromatographic and spot tests
designed to detect abnormalities in the types or concentrations
of metabolites in body fluids. Urine is usually submitted as the
material for initial studies.
Hematologic Evaluation
If the initial evaluation suggests an inherited hematologic
defect, erythrocyte and leukocyte function tests are performed,
including erythrocyte membrane, hemoglobin, and enzyme screens,
as well as leukocyte function studies.
Other Biochemical Studies =
Results of histologic studies and/or metabolic screening
determine the additional studies required. Such examinations
include studies of the concentrations of specific substrates in
tissues by gas/liquid chromatography and mass spectrometry and
fluids and assays of specific enzymes.
Cytogenetic Studies =
Currently these studies are confined to the dog and cat and
include standard and Giemsa-banded karyotyping and fluorescence
in situ by hybridization (FISH). These studies are available only
on a limited basis and are conducted only when preliminary
studies yield sufficient evidence to suspect a chromosomal
anomaly.
Pedigree Analysis =
When family data are available or family studies are possible,
the center classifies the phenotype of family members and
examines pedigree patterns for consistency with various modes of
inheritance.
Breeding Studies =
The center maintains an animal colony facility that can house a
limited number of affected animals and their close relatives for
breeding experiments designed to verify whether a defect is
heritable and to determine the mode of inheritance. These studies
depend on whether affected animals and their relatives can be
obtained as donations or purchased.
Fees for Diagnostic Services =
There is no charge for initial consultation with veterinarians
and other investigators. Subsequent studies also are without
charge if deemed appropriate by investigators at the center. When
clinical and postmortem examinations are primarily in the
interest of an animal's owner, the owner is charged, usually at a
reduced rate.
Animals =
Another objective of the center is to establish a small breeding
colony for each promising model. The center does not serve as a
source of animals for outside investigators, but makes breeding
animals or semen available to those who wish to start their own
breeding colonies once initial characterization is completed.
Breeding stock or semen is available for these models:
Hereditary defects of the conotruncal septum (tetralogy of
Fallot, ventricular septal defect, persistent truncus
arteriosus): Keeshond dog.
Hereditary patent ductus arteriosus: Dog.
Mucopolysaccharidosis VI (aryl sulfatase B deficiency): Cat.
Phosphofructokinase deficiency (glycogenosis type VII): Dog.
Squirrel Monkey Breeding and Research Resource
Primate Research Laboratory
College of Medicine
University of South Alabama
Mobile, AL 36688
(205) 460-6239
FAX: (205) 460-7783
Principal Investigator
Christian R. Abee, D.V.M.
Contact =
Christian R. Abee, D.V.M.
E-mail: usacra@asnusa.asn.net
Research Emphases
Basic Research Mission
To carry out multidisciplinary studies of reproduction in captive
Bolivian squirrel monkeys and to provide a resource of
laboratory-born and laboratory-reared animals for NIH-sponsored
research programs.
Current Research
Characterizing factors that influence captive reproduction with
emphasis on developing methods to improve reproductive potential.
A multidisciplinary approach incorporating behavioral studies,
reproductive endocrinology, medical primatology, and genetics is
ongoing.
=
Resources Provided
To Outside Investigators
Specimens
Tissues and body fluids are available. Such specimens are
provided on a priority basis to NIH-sponsored research projects
that are related to the objectives of this project. Costs of
packaging and shipping are negotiated on an individual basis to
be determined by the nature of the collaboration.
To Collaborating Scientists and Graduate Students
Individuals interested in collaborative studies must provide a
protocol to the principal investigator. Approval of collaborative
projects depends on the relevance of the proposed project to the
objectives of the ongoing research effort. Complete animal
husbandry, medical care, and pathology services are available
without charge to investigators with approval from the principal
investigator to use resource colony animals.
Animals =
The breeding colony currently contains approximately 320 Bolivian
squirrel monkeys of varying ages. Some offspring and reproductive
culls are available.
Core Staff
Includes investigators conducting studies of medical primatology,
reproductive endocrinology, data management, primate management
and husbandry, primate behavioral psychology, and genetics.
Guest Investigators and Graduate Students =
Guest investigators and graduate students interested in studies
of factors influencing reproduction of squirrel monkeys in
captivity are invited to send letters of interest. These letters
will be considered based on the relevance of the applicant's
interests to the ongoing research effort and the availability of
resources to meet the needs of the guest investigator.
Transgenic and Targeted Mutant Preservation
The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609-1500
(207) 288-3371
FAX: (207) 288-8982
Principal Investigator
Muriel T. Davisson, Ph.D.
Director of Genetic Resources
=
Contact =
All strains held by the IMR may be ordered by calling Jackson
Laboratory's Animal Resources, Production and Distribution
Department at (800) 422-6423.
=
A list of the strains currently available can be obtained by
telephoning the same number. For more information about the
resource, contact John Sharp, Ph.D., x 1441, or Muriel T.
Davisson, Ph.D., x 1340.
Research Emphases
Research is being conducted on cryopreservation techniques. All
mutations are placed on a defined genetic background if they
arrive at the Laboratory on a segregating genetic background.
Most of the targeted mutants arrive on a mixed 129xC57BL/6
background and these strains are distributed as such while the
mutation is being backcrossed onto an inbred strain (usually
C57BL/6J). In addition, new mouse models are being created by
breeding carriers of specific transgenes and/or targeted
mutations.
Resources Provided
New Technology/Procedures/Services =
Researchers can ask to have their transgenic animals considered
for inclusion in the repository. Animals with specific genes
mutated by homologous recombination (targeted mutations),
chemical mutagenesis, and retroviral insertion; and animals
carrying specific transgenes (transgenics) are held in the
Induced Mutant Resource (IMR). Animals are listed by category
below. This list, compiled in February 1994, is necessarily out
of date because four to six strains are being added per month. =
1. Mutants produced by homologous recombination (mutation type:
KO): 5-lipoxygenase, anti-Mullerian hormone (Amh), apolipoprotein
AI (Apoa1), apolipoprotein B (Apob), apolipoprotein CIII (Apoc3),
apolipoprotein E (Apoe), beta-2 microglobulin (B2m), cystic
fibrosis transmembrane conductance regulator (Cftr), cytochrome
b(-245) beta polypeptide (Cybb), DNA
(cytosine-5)-methyltransferase (Dnmt), estrogen receptor (Estr),
FBJ osteosarcoma oncogene (Fos), gap junction membrane channel
protein alpha-1 (Gja1), hemoglobin beta-chain (Hbb), hepatic
lipase (Hpl), intercellular adhesion molecule 1 (Icam1), integrin
beta-2 (CD18) (Itgb2), Jun oncogene (Jun), low density
lipoprotein receptor (Ldlr), metallothionein I (Mt1),
metallothionein II (Mt2), nerve growth factor receptor (Ngfr),
recombination activating gene-1 (Rag1), retino-blastoma-1 (Rb1),
P-selectin (Selp), T-cell receptor alpha-chain (Tcra), T-cell
receptor beta-chain (Tcrb), T-cell receptor delta-chain (Tcrd),
transforming growth factor-alpha (Tgfa), transforming growth
factor-beta 1 (Tgfb1), transformation-related protein 53 (Trp53),
twist (Twist). =
2. Mutants produced by chemical mutagenesis (mutation type:
chemical): hypoxanthine phosphoribosyltrans-ferase (Hprt),
multiple intestinal neoplasia (Min), phenylalanine hydroxylase
(Pah).
3. Mutants produced by retroviral insertion (mutation type:
4. Transgenic mice (mutation type: transgenic): apolipoprotein AI
Animal Resource Support for Biomedical Research
Johns Hopkins University
Principal Investigator
Contact =
John D. Strandberg, D.V.M., Ph.D. =
E-mail: jstrand@welchlink.welch.jhu.edu
Robert J. Adams, D.V.M.
Research Emphases
To recognize, define, and investigate abnormal conditions and
Current Research
Resources Provided
New Technology/Procedures/Services =
Transgenic mouse biology.
Diagnostic Services =
This laboratory is staffed to provide general competence in gross
Diagnostic Research and Clinical Laboratory Program
Laboratory Animal Research Center
1230 York Avenue
=
Principal Investigator
Contact =
Inquiries (by telephone, letter, or FAX) about diagnostic
Research inquiries (research applications, technology) to Stephen
E-mail: morse@rockvax.rockefeller.edu.
Research Emphases
Basic Objectives =
To develop and provide diagnostic services and methodology, and
Current Research
Resources Provided
New Technology/Procedures/Services =
Polymerase chain reaction (PCR) detection of retroviruses
Diagnostic Services =
This laboratory, with Cornell University Medical College, the
Laboratory Animal Resource for Biomedical Research
University of Alabama at Birmingham
=
Principal Investigator
Contact =
J. Russell Lindsey, D.V.M.
Research Emphases
Basic Objectives
Current Research
=
Resources Provided
Diagnostic Services =
This laboratory is staffed to provide broad competence in
Other Services =
Investigation of new animal models for human diseases. The
Research Animal Diagnostic Laboratory
Massachusetts Institute of Technology
Principal Investigator
Coprincipal Investigator
Contact =
James G. Fox, D.V.M.
Research Emphases
Basic Objectives =
To maintain the quality of research animals through control and
Current Research
Resources Provided
Diagnostic Services
Yale University School of Medicine
=
Principal Investigator
Contact =
Robert O. Jacoby, D.V.M., Ph.D. =
Transgenic mouse production unit and embryo cryopreservation
Hybridoma laboratory, (203) 785-2535
Cytochemistry laboratory, (203) 785-2520
Virology and serology laboratory, (203) 785-2535
Animal immunization service, (203) 785-2501
Research Emphases
Basic Objectives =
To maintain the quality of research animals through control and
Current Research
Resources Provided
New Technology/Procedures/Services =
Transgenic mouse production, embryo cryopreservation, polyclonal
Diagnostic Services =
This laboratory is staffed to provide general competence in gross
Cryopreservation of Murine Germplasm
The Jackson Laboratory
Principal Investigator
Contact =
Larry E. Mobraaten, Ph.D., E-mail: lem@jax.org =
The Jackson Laboratory Animal Resources, (800) 422-MICE or =
(207) 288-5845; FAX: (207) 288-3398
Research Emphases
Basic Objective
Current Research
Resources Provided
Reference Services =
The repository contains frozen eight-cell mouse embryos from
Northwestern University
Principal Investigator
Grantee Institutional Organization
Contact =
Linda Johnson, D.V.M., M.S., M.P.H., The Registry of Comparative
E-mail: johnson@afip.osd.mil. =
Research Emphases
Basic Objective
Resources Provided
The Registry of Comparative Pathology sponsors two medical or
The Marine Mammal Database, a computer-accessible reference
=
Reference Services
Consultation Available
Institute of Laboratory Animal Resources
Principal Investigator
Contact =
Research Emphases
Basic Objective
Resources Provided
Activities =
The Institute of Laboratory Animal Resources (ILAR) develops
Laboratory Primate Newsletter
Brown University
Principal Investigator
Editor
Contact
=
Research Emphases
Basic Objective
Resources Provided
Reference Services
Primate Supply Information Clearinghouse
Primate Information Center
Principal Investigator
Project Coordinator
Contact =
Cathy A. Johnson-Delaney, D.V.M.
Research Emphases
Basic Objective
Resources Provided
Services =
The clearinghouse matches research needs for nonhuman primates
Services are available without charge to government-supported
Principal Investigator
Number of Trainees
Major Areas of Interest
Principal Investigator
=
Number of Trainees
Major Areas of Interest
Principal Investigator
Number of Trainees
Major Areas of Interest
How to Access Services
University of Florida
Principal Investigator
Number of Trainees
Major Areas of Interest
Johns Hopkins University
Principal Investigator
Number of Trainees
Major Areas of Interest
Harvard Medical School/New England Regional Primate Research
Center
Principal Investigator
Number of Trainees
Major Areas of Interest
Massachusetts Institute of Technology
Principal Investigator
James G. Murphy, D.V.M., Ph.D.
Number of Trainees
Major Areas of Interest
University of Michigan
Principal Investigator
Number of Trainees
Major Areas of Interest
University of Missouri-Columbia
Principal Investigator
Codirectors
Number of Trainees
Major Areas of Interest
Wake Forest University
Principal Investigator
Number of Trainees
Major Areas of Interest
Pennsylvania State University
Principal Investigator
Number of Trainees
Major Areas of Interest
University of Texas Southwestern Medical Center, Dallas
Principal Investigator
Number of Trainees
Major Areas of Interest
University of Washington
Principal Investigator
Contact
Number of Trainees
Major Areas of Interest
immune responses; parasite-host relationships of helminths and
Principal Investigator
Send a resume and, if possible, a specific area of =
research interest.
=
Number of Trainees
Major Areas of Interest
Principal Investigator
Pathology
Number of Trainees
Major Areas of Interest
biotechnology, vaccine development, genetic diseases =
of animals, cardiovascular diseases, and thrombosis.
Alabama
* Animal Diagnostic/Investigative Laboratory Resource
* Institutional Training Award
Arizona
California
* SPF-Macaque Breeding and Research Resource
* Institutional Training Award
Connecticut
* Institutional Training Award
District of Columbia
=B7 Information Project
Florida
* Institutional Training Award
Georgia
* Chimpanzee Breeding and Research Resource
Illinois
Louisiana
* Chimpanzee Breeding and Research Resource
Maine
Mouse Mutant Gene Resource (Bar Harbor)
* Animal Reference Center
Maryland
* Institutional Training Award
Massachusetts
* SPF-Macaque Breeding and Research Resource
* Animal Diagnostic/Investigative Laboratory Resource
* Institutional Training Award
Michigan
* Institutional Training Award
Minnesota
Missouri
New Mexico
New York
North Carolina
* Institutional Training Award
Puerto Rico
Rhode Island
South Carolina
Texas
* SPF-Macaque Breeding and Research Resource
* Special Animal Colony and Model Study
* Institutional Training Award
* Short-Term Training Award: Students in Health Professional
Texas A & M Research Foundation (College Station)
Washington
* Information Project
* Institutional Training Award
* Short-Term Training Award: Students in Health Professional
Washington State University (Pullman)
Wisconsin
Name Index
Apple Valley, MN
Fox, James G., Research Animal Diagnostic Laboratory, Cambridge,
Therefore, all programs of the National Center for Research
retroviral insertion): procollagen type1 alpha-1 (Mov13)
(Cola1
[human] gN(APOA1-2)1Rub; apolipoprotein AII
[human] gN(APOA2)3Rub; apolipoprotein E [human] gN(APOE)4Rub;
hepatitis B virus large envelope polypeptide-mouse albumin
promoter gN(Alb1HBV)44Bri; CD3 antigen, epsilon polypeptide
[human] gN(CD3E); metallothionein I [mouse] gN(Mt1)174Bri;
rat insulin II promoter-SV40 large-T antigen gN(Rip-Tag)1Lt;
SV40 large T-antigen gN(SV)7Bri;
beta-galactosidase gR(ROSA26)26Sor.
720 Rutland Avenue
Baltimore, MD 21205
(410) 955-3273
FAX: (410) 955-9823
John D. Strandberg, D.V.M., Ph.D.
Basic Objectives =
diseases of animals that may interfere with biomedical research;
to identify and explore animal models of human disease; to
facilitate development of improved humane techniques for
animal-based research.
Biology, molecular biology, and pathogenesis of animal lentiviral
infections including visna-maedi (sheep), caprine
encephalitis-arthritis virus, and primate lentivirus as models of
human AIDS; etiology and pathogenesis of enteric bacterial
infections; Borna virus infection; fish as environmental
monitors; hepatic toxicology and carcinogenesis in fish;
evaluation of animal and in vitro models for carcinogenesis risk
assessments; development of an SPF nonhuman primate colony;
canine, murine, and primate models of benign prostatic
hyperplasia; use of animals in development of interventional
radiologic techniques; animal models of radioimmunotherapy in
oncology; bone integration in surgical hip replacement
procedures.
and microscopic pathology, virology, microbiology, parasitology,
clinical chemistry, and hematology in support of animal research
and related clinical problems. Diagnostic resources are designed
primarily to serve the grantee and affiliated institutions.
However, with approval by the principal investigator, they are
available for collaboration in investigating laboratory animal
disease problems.
Rockefeller University, Box 2 =
New York, NY 10021
(212) 327-8535
FAX: (212) 327-7974
Michael D. Hayre, D.V.M.
services to Michael D. Hayre, D.V.M.
S. Morse, Ph.D., or Pamela B. Moore, Ph.D., Box 120, Rockefeller
University, 1230 York Avenue, New York, NY 10021, (212) 327-8594;
FAX: (212) 327-7172 or 327-7974; =
to carry out research studies on viral infections of laboratory
animals, including screening or testing of samples for our target
viruses (lentiviruses, hantaviruses, and mouse thymic virus).
Submissions are encouraged.
Development of rapid immunodiagnostic assays; the biology of
thymic necrosis virus (murid herpesvirus 3); macrophage biology;
molecular methods for detection of retroviruses, hantaviruses,
and murid herpesviruses; viral superantigens and their effects on
T-cell development.
(especially lentiviruses), hantaviruses, and herpesviruses;
ELISA, PCR for mouse thymic virus (murid herpesvirus 3).
Sloan-Kettering Institute, and the Animal Medical Center,
provides a complete laboratory animal diagnostic program. The
Rockefeller University laboratory is specifically staffed to
provide expertise in microbiology, serology, virus isolation (for
certain viruses), pathology, and parasitology. The laboratory
primarily serves the grantee and affiliated institutions.
Collaborative diagnostic and research programs related to
laboratory animal science are encouraged with other institutions.
UAB Station
Birmingham, AL 35294
(205) 934-2117
FAX: (205) 975-4418
J. Russell Lindsey, D.V.M.
Research investigations to solve problems affecting the use of
animals in research, particularly problems concerning infectious
diseases and new animal model discovery and development.
Additionally, the program seeks to improve the quality of animal
research locally and nationally through the dissemination and
application of research findings, and to encourage educational
and training opportunities for veterinary students,
veterinarians, graduate students, investigators, and technical
personnel.
Emphasis is given to five major projects: the prevalence and
importance of cilia-associated respiratory bacillus (CARB) in
rats and mice; derivation of a mycoplasma-free F344 rat stock;
detection of coronaviruses by nucleic acid hybridization assay; a
reproducible model of Reye syndrome; and molecular genetic
monitoring of inbred strains of mice. A modest component of the
program is diagnostic problem solving, an indispensable tool for
identifying and solving animal health problems.
pathology, microbiology, mycoplasmology, parasitology, clinical
chemistry, hematology, and genetics, and has special expertise in
infectious diseases of rodents. Diagnostic resources are designed
primarily to serve the grantee and affiliated institutions.
However, with approval by the principal investigator, they are
available for collaboration in investigating laboratory animal
disease problems.
resource is interested in having potential new animal models
referred for investigation or development.
77 Massachusetts Avenue
Cambridge, MA 02139
(617) 253-1757
FAX: (617) 258-5708
James G. Fox, D.V.M.
James C. Murphy, D.V.M., Ph.D.
diagnosis of diseases within research animal facilities at the
Massachusetts Institute of Technology and other animal research
facilities in the greater Boston area. To recognize and define
abnormal physiologic conditions and comparative diseases that may
be of interest to biomedical researchers.
Characterization of the biology and medicine of the ferret
(Mustela putorius furo); Helicobacter spp. and their role in
gastrointestinal disease in laboratory animals; pathogenesis of
helicobacteriosis in humans and animals; role of Desulfovibrio
species in proliferative bowel disease; role of clostridial
toxins in development of enteropathy in rabbits; pathogenesis of
Aleutian disease, lymphoma, and hypereosinophilic syndrome in
ferrets; development of animal models for Helicobacter-associated
gastric disease and Lyme disease.
This laboratory is staffed to provide general competence in gross
and microscopic pathology, microbiology, parasitology, clinical
chemistry, hematology, and diagnostic virology. Diagnostic
resources are designed primarily to serve the grantee and
affiliated institutions. However, with approval by the principal
investigator, they are available for collaboration in
investigating laboratory animal disease problems.
Resource for the Study of Laboratory Animal Diseases
P. O. Box 208016
333 Cedar Street
New Haven, CT 06520-8016
(203) 785-2525
FAX: (203) 785-7499
Robert O. Jacoby, D.V.M., Ph.D.
unit, (203) 785-2534 or 785-6923 =
diagnosis of diseases within animal research facilities at the
Yale University School of Medicine. To recognize and define
conditions and diseases that may be of interest to biomedical
research.
Pathobiology of mousepox, mouse hepatitis virus, rat
coronaviruses, and rodent parvovirus infections; mechanisms of
persistence in viral infection of rodents; immunosuppression
induced by murine viruses; animal models of Lyme disease;
viral-induced cancer; viral pneumonia in the aged; and endocrine
control of bone metabolism.
antibody production, hybridoma and monoclonal antibody
production, in situ hybridization.
and microscopic pathology, microbiology, parasitology, virology,
and serology; and has special expertise in viral diseases of
rodents. Diagnostic resources are designed primarily to serve the
grantee and affiliated institutions. However, with approval by
the principal investigator, they are available for collaboration
in investigating laboratory animal disease problems. =
600 Main Street
Bar Harbor, ME 04609
(207) 288-3371 x 1235
FAX: (207) 288-5079
Larry E. Mobraaten, Ph.D.
To assure the safe preservation of scientifically valuable
strains of laboratory mice by establishing a bank of frozen mouse
embryos. At present the program staff is freezing and storing in
liquid nitrogen embryos from selected strains of the more than
1,700 inbred and mutant strains of mice maintained at the Jackson
Laboratory. Other objectives are to reduce the necessary number
of different stocks or size of colonies maintained by
conventional breeding procedures and to retard genetic drift.
Cryopreservation of mouse embryos and spermatozoa.
genetically defined strains of laboratory mice that are
maintained at the Jackson Laboratory. Embryos from more than
1,150 different strains are currently preserved. Breeding pairs
of mice are made available when such mice cannot be obtained from
conventional breeding sources.
Registry of Comparative Pathology
303 East Chicago Avenue
Chicago, IL 60611
(312) 503-0389
FAX: (312) 503-8240
Dante G. Scarpelli, M.D., Ph.D.
Universities Associated for Research and Education in
Pathology, Inc.
9650 Rockville Pike
Bethesda, MD 20814
Pathology, Armed Forces Institute of Pathology, Washington, DC
20306-6000; (202) 576-2452; FAX: (202) 576-9161; =
To collect, classify, and study diseases of comparative pathology
interest. To disseminate knowledge about comparative aspects of
disease. To use knowledge of diseases in many animal species to
benefit humanity. The reference center, located in the Armed
Forces Institute of Pathology (AFIP) on the campus of the Walter
Reed Army Medical Center in Washington, D.C., is administered
jointly by Universities Associated for Research and Education in
Pathology (UAREP) and the AFIP. Its registry advisory committee
is chaired by Dr. Dante Scarpelli, professor of pathology at
Northwestern University Medical School in Chicago, and includes
outstanding Pathologists who have special experience and interest
in comparative pathology.
=
A CD-ROM illustrating select animal models by integrating color
images, text, legends, and references has been produced and is
available to medical and veterinary medical libraries in the
United States. Included on the CD-ROM are the directories,
Educational Opportunities in Comparative Pathology in the United
States and Foreign Countries and Veterinary Pathology and
Veterinary Clinical Pathology Training Programs in North American
Colleges and Schools of Veterinary Medicine.
veterinary medical summer research assistants to assist in
ongoing research projects at AFIP. This competitive program
matches a student with a senior investigator conducting
comparative studies research.
source, was compiled by the Registry of Comparative Pathology and
the Department of Veterinary Pathology at AFIP. This database
contains case information on one of the world's largest
collections of archived marine mammal tissue. Approximately 1,200
cases, representing whales, dolphins, seals, sea lions, walruses,
sea otters, and polar bears, are referenced by tissue, disease,
and etiology. =
The registry maintains increasing collections of tissue and
illustrative material, all indexed in a "natural language"
computerized file and available for study. Scientists can use
materials for research training, research, or preparation for
teaching. Registry personnel conduct workshops, symposia, and
short courses; prepare exhibits; and loan study sets and syllabi.
A listing of the registry's study sets is contained in the List
of Education Aids of the Armed Forces Institute of Pathology. The
registry publishes the quarterly Comparative Pathology Bulletin;
the Handbook: Animal Models of Human Diseases; and three
directories: Educational Opportunities in Comparative Pathology
in the United States and Foreign Countries, Veterinary Pathology
and Veterinary Clinical Pathology Training Programs in North
American Colleges and Schools of Veterinary Medicine, and
Resources of Biomedical and Zoological Specimens. Principal types
of service requests include those for animal models, pathological
material from specific animal species, and for specific
information about diseases in animals, methodology, training, and
career opportunities.
Consultation is available on histopathology of all animal cases
of interest from a comparative standpoint, especially those that
may have implications regarding human disease or models of human
disease. Services are provided to investigators on a cooperative
basis.
Institute of Laboratory Animal Resources
National Research Council
2101 Constitution Avenue, NW
Washington, DC 20418
(202) 334-2590
FAX: (202) 334-1687
Thomas L. Wolfle, D.V.M., Ph.D.
To develop and make available to the biomedical community
scientific and technical information, guidelines, surveys, and
directories as a service to improve the availability, quality,
and use of laboratory animals.
guidelines on laboratory animal care and use, and conducts
conferences, symposia, and workshops on important laboratory
animal problems. ILAR publishes the journal ILAR News on a
quarterly basis, as well as conference proceedings and special
reports prepared by committees of experts. Listings of animal
sources are compiled by ILAR staff members and published
occasionally. A list of ILAR publications on laboratory animals
is available. As a part of the Animal Models and Genetic Stocks
Information Exchange Program, ILAR staff members answer direct
telephone and mail inquiries on the existence and location of
specific animal models; correct nomenclature to identify animals;
and related topics such as facilities, diseases of animals, and
relevant publications. ILAR also aids in the relocation of
genetic stocks that cannot be maintained at their original sites.
Box 1853
Providence, RI 02912
(401) 863-2048
FAX: (401) 863-1300
Michael J. Walker, Ph.D.
Judith E. Schrier, M.Sc.
Judith E. Schrier, M.Sc., (401) 863-2511. E-mail on Bitnet
primate@brownvm; on other networks primate@brownvm.brown.edu. =
To provide news and information that will be of help and
interest to persons involved in research with nonhuman primates.
=
The resource has published the Laboratory Primate Newsletter
quarterly since 1962. Major categories of information provided
are the care, breeding, and supply of nonhuman primates for
laboratory studies; general information and news bearing on
research with nonhuman primates; requests for research material
or for information related to specific research problems; and
conservation of nonhuman primates. A Directory of Graduate
Programs in Primatology and Primate Research is issued
periodically. The mailing list is limited to persons who have a
legitimate, relatively long-term professional connection with
primate research either directly or in some supportive role.
Current issues are free of charge; back issues are available for
$3 each (checks payable to Brown University). The Newsletter is
available by electronic mail through an electronic list. To
subscribe by BITNET, send the message: Subscribe LPN-L
your-own-name, to listserv@brownvm. From other networks send that
message to listserv@brownvm.brown.edu.
Washington Regional Primate Research Center
SJ-50
University of Washington
Seattle, WA 98195
(206) 543-5178
FAX: (206) 685-0305
E-mail: psic@u.washington.edu
Douglas M. Bowden, M.D.
Cathy A. Johnson-Delaney, D.V.M.
=
To promote conservation of nonhuman primates by reducing
laboratory demand on wild populations. To make the best possible
use of available research primates in the United States by
facilitating the sequenced use of nonhuman primates in biomedical
research and to effect speedier communication among users.
Investigators and colony managers are invited to list their
animals available for transfer or to be shared and to consult the
clearinghouse regarding availability of animals, etc., for new
projects.
=
and primate materials such as blood samples, tissues, and
cadavers, with resources available from other institutions. Any
needs and availabilities that are not immediately matched are
published in New Listings Primate Supply Information
Clearinghouse. The clearinghouse also has a database on colonies
and other possible sources of primates and primate materials to
which notices of availability and need can be referred.
researchers and to other scientists in the United States using
primates in their work. Services except New Listings are also
available to scientists in other countries.
Institutional Training Awards
University of Alabama
at Birmingham
J. Russell Lindsey, D.V.M.
Professor and Chairman
Department of Comparative Medicine
Schools of Medicine and Dentistry
University of Alabama at Birmingham
Birmingham, AL 35294
(205) 934-2117
FAX: (205) 975-4418
Six trainees
Cellular and molecular mechanisms in inherited metabolic
diseases; gene expression and therapy; transgenic/embryonic stem
cell animal modeling; role of integrins in urinary tract disease;
pathogenesis of mycoplasmal and viral diseases; regulation of
respiratory immune responses; and pathogenesis of cardiovascular
disease.
University of California, Davis
Bennie I. Osburn, D.V.M., Ph.D.
Dean's Office
School of Veterinary Medicine
University of California, Davis
Davis, CA 95616
(916) 752-6865
FAX: (916) 752-2801
E-mail: biosburn@ucdavis.edu
Four trainees
=
Comparative pathology, epidemiology, physiology, nutrition, and
microbiology/immunology.
Yale University =
Robert O. Jacoby, D.V.M., Ph.D.
Yale University School of Medicine
P. O. Box 208016
333 Cedar Street
New Haven, CT 06520-8016
(203) 785-2525
FAX: (203) 785-7499
Four trainees
Viral disease of laboratory animals. Rodent diseases infections
caused by parvoviruses, mouse hepatitis viruses, ectromelia
virus, Sendai virus, rat coronaviruses, and several others.
Animal models of human diseases, particularly models of Lyme
disease, viral-induced cancer, and endocrine control of bone
metabolism.
=
For information, contact the Postgraduate Training Committee at
address above.
A. F. Moreland, D.V.M.
Professor and Program Director
Laboratory Animal Comparative Medicine
Department of Small Animal Clinical Sciences
University of Florida
College of Veterinary Medicine
P. O. Box 100006
Gainesville, FL 32610-0006
(904) 392-2977
FAX: (904) 392-3766
Four trainees
The program provides opportunities for education and research in
comparative and experimental pathology, immunobiology,
microbiology, infectious diseases and physiology, as well as
pathogenesis, control, and treatment of laboratory animal
diseases. The Health Sciences Center includes colleges of
medicine, veterinary medicine, dentistry, pharmacy, nursing, and
health-related professions, so opportunities are available for
individual or collaborative research using virtually all species
of laboratory animals and domestic livestock.
=
John D. Strandberg, D.V.M., Ph.D.
Division of Comparative Medicine
Johns Hopkins University
School of Medicine
Baltimore, MD 21205
(410) 955-3273
FAX: (410) 550-5068
E-mail: jstrand@welchlink.welch.jhu.edu
=
Six trainees
=
Laboratory animal medicine and comparative pathology. Retroviral
diseases of animals and humans, comparative neurovirology and
neuropathology, Alzheimer's disease and aging, benign prostatic
hyperplasia, fish pathology, enteric infections of laboratory
animals, interventional radiology, and experimental surgery.
Norval W. King Jr, D.V.M.
Harvard Medical School
New England Regional Primate Research Center (NERPRC)
One Pine Hill Drive
P.O. Box 9102
Southborough, MA 01772-9102
(508) 624-8157
FAX: (508) 460-0612
Six trainees
Research training in comparative and veterinary pathology. Animal
models of human diseases.
James G. Fox, D.V.M., Ph.D.
Professor and Director
Division of Comparative Medicine
Massachusetts Institute of Technology
37 Vassar Street, 45-106
Cambridge, MA 02139
(617) 253-1757
FAX: (617) 258-5708
Codirector
Four trainees
Pathogenesis of infectious diseases of laboratory animals, with
particular emphasis on the gastrointestinal tract. Development of
animal models for biomedical research. Study of the biology and
medicine of the ferret (Mustela putorius furo).
Daniel H. Ringler, D.V.M.
University of Michigan
Unit for Laboratory Animal Medicine
018 Animal Research Facility
Ann Arbor, MI 48109-0614
(313) 764-0277
FAX: (313) 936-3235
Internet daniel.h.ringler@um.cc.umich.edu
Six trainees
Bacterial virulence and mechanisms of disease focusing primarily
on cytokines, pneumocystis, cryptosporidiosis, legionella in
animal models; bacterial pathogenesis using Vibrio cholera as the
model system; definition of the spectrum of spontaneous
degenerative and neoplastic age-associated lesions in mice and
rats; investigation and characterization of spontaneous and
iatrogenic diseases of laboratory animals; also, hypertension,
tumor immunology, cardiac physiology, mechanisms of pain,
thermoregulation, cardiovascular pharmacology, reproductive
endocrinology, diabetes mellitus, and immunoregulation.
Ronald M. McLaughlin, D.V.M.
Laboratory Animal Medicine Area Program (LAMAP)
M-144 Medical Science Building
School of Medicine
University of Missouri-Columbia
Columbia, Mo 65212
(314) 882-3111
Joseph E. Wagner, D.V.M., Ph.D
Cynthia Besch-Williford, D.V.M., Ph.D.
Richard E. Fish, D.V.M., Ph.D.
Six trainees
Laboratory animal diseases and pathology. The LAMAP uses
established investigators as research mentors in such areas as
reproductive physiology, immunology, rheumatology, microbiology,
and animal science.
Thomas B. Clarkson, D.V.M.
Bowman Gray School of Medicine
Wake Forest University
Medical Center Boulevard
Winston-Salem, NC 27157-1040
(910) 716-7045
FAX: (910) 764-5818
E-mail: tclarkson@cmp.bgsm.wfu.edu
Six trainees
Animal models of inherited metabolic disease; experimental
cardiology; metabolic bone diseases; animal models of
atherosclerosis; behavioral medicine; primate reproductive
medicine; and comparative ophthalmology.
C. Max Lang, D.V.M.
George T. Harrell Professor and
Chairman of Comparative Medicine
Milton S. Hershey Medical Center
Pennsylvania State University
College of Medicine
Hershey, PA 17033
(717) 531-8462
FAX: (717) 531-7557
Four trainees
Analgesia, anesthesia, and euthanasia; animal models of human
disease; environmental factors that may affect the interpretation
of research data; spontaneous diseases of laboratory animals.
Steven P. Pakes, D.V.M., Ph.D.
University of Texas Southwestern Medical Center
at Dallas
5323 Harry Hines Boulevard
Dallas, TX 75235-9037
(214) 648-3340
FAX: (214) 648-2659
Four trainees
Pathogenesis, control, and prevention of murine mycoplasmosis;
cellular tropism, neurovirulence, and neuropathogenesis of feline
immunodeficiency virus (FIV); pathophysiology of hematopoietic
dysfunctions in FIV-infected cats; development of polymerase
chain reaction (PCR) assays for rapid diagnosis of common rodent
diseases caused by mycoplasma and viruses.
Gerald L. Van Hoosier, D.V.M.
Department of Comparative Medicine
SB-42
School of Medicine
University of Washington
Seattle, WA 98195
(206) 543-8047
FAX: (206) 685-3006
E-mail: gvanhoosier@cmed.cmo.washington.edu
Melvin B. Dennis, Jr., D.V.M.
Associate Professor and Coordinator of Academic Programs
Six trainees
The effects of subclinical viral infections on host =
zoonotic diseases; pasteurellosis and venereal spirochetosis;
comparative oncology; virology; hematopoiesis; hematopoietic
response to diseases; blood access and artificial organs; and
SAIDS-D immunodeficiency.
Short Term Training Awards: Students in Health Professional Schools
Texas A M Research Foundation
Raymond F. Sis, D.V.M., Ph.D.
Professor of Veterinary Anatomy/Public Health
College of Veterinary Medicine
Texas A & M University
College Station, TX 77843
(409) 845-4889
FAX: (409) 847-8981
Fifteen predoctoral trainees
=
Exploring research as a career option; short-term research
training for veterinary students during the summer months in
genetics, aquatic pathobiology, infectious diseases,
reproduction, and toxicology in the Texas A&M University College
of Veterinary Medicine.
Washington State University
David J. Prieur, D.V.M., Ph.D.
Professor of Veterinary Microbiology and =
Bustad Hall
Washington State University
Pullman, WA 99164-7040
(509) 335-6030
FAX: (509) 335-8529
Nine predoctoral veterinary trainees
Infectious diseases of animals, neuroscience, =
Geographic Index
* Special Animal Colony and Model Study
Squirrel Monkey Breeding and Research Resource (Mobile)
Laboratory Animal Resource for Biomedical Research
(Birmingham)
University of Alabama at Birmingham =
* Chimpanzee Breeding and Research Resource
Primate Foundation of Arizona (Mesa)
* Regional Primate Research Center
California Regional Primate Research Center (Davis)
Simian Retrovirus Reference Laboratory (Davis)
Genetics Typing Laboratory (Davis)
University of California (Davis)
* Animal Diagnostic/Investigative Laboratory Resource
Resource for the Study of Laboratory Animal Diseases (New
Haven)
Yale University (New Haven)
* Animal Reference Center
Registry of Comparative Pathology (Washington)
Institute of Laboratory Animal Resources (Washington)
* SPF-Macaque Breeding and Research Resource
Specific-Pathogen-Free Rhesus Monkeys (Miami)
University of Florida (Gainesville)
* Regional Primate Research Center
Yerkes Regional Primate Research Center (Atlanta)
Chimpanzee Breeding and Research Colony (Atlanta)
* Animal Reference Center
Registry of Comparative Pathology (Chicago)
* Regional Primate Research Center
Tulane Regional Primate Research Center (Covington)
Chimpanzee Breeding and Research Colony (New Iberia)
* Special Animal Colony and Model Study
Enhancing the Mouse Resource: Recombinant Inbred Strains
(Bar Harbor)
Transgenic and Targeted Mutant Preservation (Bar Harbor) =
Cryopreservation of Murine Germplasm (Bar Harbor)
* Animal Diagnostic/Investigative Laboratory Resource
Animal Resource Support for Biomedical Research (Baltimore)
Johns Hopkins University (Baltimore)
* Regional Primate Research Center
New England Regional Primate Research Center (Southborough)
Specific-Pathogen-Free Rhesus Monkeys (Southborough)
Research Animal Diagnostic Laboratory (Cambridge)
Harvard Medical School/New England Regional Primate Research
Center (Southborough)
Massachusetts Institute of Technology (Cambridge)
* SPF-Macaque Breeding and Research Resource
Specific-Pathogen-Free Rhesus Monkeys (Lansing)
University of Michigan (Ann Arbor)
* Chimpanzee Breeding and Research Resource
Captive Population Dataset Assembly and Tracking, Analysis,
and Modeling (Apple Valley)
* Institutional Training Award
University of Missouri-Columbia
* Chimpanzee Breeding and Research Resource
Chimpanzee Breeding and Research Colony (Holloman Air Force
Base)
* Animal Diagnostic/Investigative Laboratory Resource
Diagnostic Research and Clinical Laboratory Program (New
York)
* Institutional Training Award
Wake Forest University (Winston-Salem)
Oregon
* Regional Primate Research Center
Oregon Regional Primate Research Center (Beaverton)
Pennsylvania
* Special Animal Colony and Model Study
Referral Center for Animal Models of Human Genetic Disease
(Philadelphia)
Pennsylvania State University (Hershey)
* Special Animal Colony and Model Study
Caribbean Primate Research Center Program (Sabana Seca, San
Juan, and Cayo Santiago)
* Information Project
Laboratory Primate Newsletter (Providence)
* SPF-Macaque Breeding and Research Resource
Specific-Pathogen-Free Macaques (Yemassee)
* Chimpanzee Breeding and Research Resource
Chimpanzee Breeding and Research Colony (Bastrop)
Genetics Typing Laboratory for Chimpanzees (San Antonio)
Applied Research for Improving the Behavioral Management of
Captive Chimpanzees (Bastrop)
Specific-Pathogen-Free Macaques (Bastrop)
Specific-Pathogen-Free Macaque Monkeys (Alice)
B-Virus Diagnostic Resource and Research Laboratory (San
Antonio)
Applied Research for Improving the Behavioral Management of
the Captive Rhesus Monkey (Bastrop)
Genetics Laboratory for Typing Nonhuman Primates (San
Antonio)
University of Texas Southwestern Medical Center (Dallas)
Schools =
* Regional Primate Research Center
Washington Regional Primate Research Center (Seattle)
Primate Supply Information Clearinghouse (Seattle)
University of Washington (Seattle)
Schools =
* Regional Primate Research Center
Wisconsin Regional Primate Center (Madison)
Abee, Christian R., Squirrel Monkey Breeding and Research
Resource, Mobile, AL
Adams, Robert J., Animal Resource Support for Biomedical
Research, Baltimore, MD
Bard, Kim A., Chimpanzee Breeding and Research Colony, Atlanta,
GA
Baskin, Gary B., Tulane Regional Primate Research Center,
Covington, LA
Besch-Williford, Cynthia, University of Missouri-Columbia
Institutional Training Award
Bloomsmith, Mollie A., Applied Research for Improving the
Behavioral Management of the Captive Rhesus Monkey, Bastrop, TX
Applied Research for Improving the Behavioral Management of
Captive Chimpanzees, Bastrop, TX
Bowden, Douglas M., Primate Supply Information Clearinghouse,
Seattle, WA
Buchl, Stephanie J., Specific-Pathogen-Free Macaques, Bastrop, TX
Clarkson, Thomas B., Wake Forest University Institutional
Training Award, Winston-Salem, NC
Beaverton
Davisson, Muriel T., Mouse Mutant Gene Resource, Bar Harbor, ME
Transgenic and Targeted Mutant Preservation, Bar Harbor, ME
Dennis, Melvin B., Jr., University of Washington Institutional
Training Award, Seattle
Eicher, Eva M., Mouse Mutant Gene Resource, Bar Harbor, ME
Ely, John, Genetics Typing Laboratory for Chimpanzees, San
Antonio, TX
Genetics Laboratory for Typing Nonhuman Primates, San
Antonio, TX
Eppig, Janan, Enhancing the Mouse Resource: Recombinant Inbred
Strains, Bar Harbor, ME
Fish, Richard E., University of Missouri-Columbia Institutional
Training Award
Flesness, Nathan R., Captive Population Dataset Assembly and
Tracking, Analysis, and Modeling, =
MA
Massachusetts Institute of Technology Institutional Training
Award, Cambridge, MA
Fritz, Jo, Primate Foundation of Arizona, Mesa, AZ
Frost, Patrice, Chimpanzee Breeding and Research Colony, Holloman
Air Force Base, NM
Gerone, Peter J., Tulane Regional Primate Research Center,
Covington, LA
Gibaldi, Milo, Washington Regional Primate Research Center,
Seattle
Giger, Urs, Referral Center for Animal Models of Human Genetic
Disease, Philadelphia, PA =
Gould, Kenneth G., Chimpanzee Breeding and Research Colony,
Atlanta, GA
Greenhouse, Dorothy D., Institute of Laboratory Animal Resources,
Washington, DC
Greer, William E., Chimpanzee Breeding and Research Colony, New
Iberia, LA
Haskins, Mark, Referral Center for Animal Models of Human Genetic
Disease, Philadelphia, PA =
Hatcher, Charles R., Yerkes Regional Primate Research Center,
Atlanta, GA
Hayre, Michael D., Diagnostic Research and Clinical Laboratory
Program, New York, NY
Hearn, John P., Wisconsin Regional Primate Center,
Madison
Hendrickx, Andrew, G., California Regional Primate Research
Center, Davis, CA
Hilliard, Julia K., B-Virus Diagnostic Resource and Research
Laboratory, San Antonio, TX
Hunt, Ronald D., New England Regional Primate Research Center,
Southborough, MA
Insel, Thomas R., Yerkes Regional Primate Research Center,
Atlanta, GA
Jacobsen, Larry, Wisconsin Regional Primate Center,
Madison
Jacoby, Robert O., Resource for the Study of Laboratory Animal
Disease, New Haven, CT
Yale University School of Medicine Institutional Training Award,
New Haven, CT
Johnson, Kenneth R., Mouse Mutant Gene Resource, Bar Harbor, ME
Johnson, Linda, Registry of Comparative Pathology, Washington, DC
Johnson-Delaney, Cathy A., Primate Supply Information
Clearinghouse, Seattle, WA
Keeling, Michale E., Chimpanzee Breeding and Research Colony,
Bastrop, TX
Specific-Pathogen-Free Macaques, Bastrop, TX
Kessler, Matthew J., Caribbean Primate Research Center, Sabana
Seca, PR
King, Norval W., Jr., New England Regional Primate Research
Center, Southborough, MA
Harvard Medical Center/New England Regional Primate Research
Center Institutional Training Award, Southborough, MA
Kintner, Barbara A., Specific-Pathogen-Free Rhesus Monkeys,
Lansing, MI =
Kohler, Peter O., Oregon Regional Primate Research Center,
Beaverton
Kohler, Susan L., Genetics Typing Laboratory for Chimpanzees, San
Antonio, TX
Genetics Laboratory for Typing Nonhuman Primates, San Antonio, TX
Lang, C. Max, Pennsylvania State University College of Medicine
Institutional Training Award, Hershey, PA
LeRosa, John C., Tulane Regional Primate Research Center,
Covington, LA
Lee, D. Rick, Chimpanzee Breeding and Research Colony, Bastrop,
TX
Lee-Parritz, David, Specific-Pathogen-Free Rhesus Monkeys,
Southborough, MA
Lerche, Nicholas W., Simian Retrovirus Reference Laboratory,
Davis, CA
Lindsey, J. Russell, Laboratory Animal Resource for Biomedical
Research, Birmingham, AL
University of Alabama at Birmingham Institutional Training Award
Lukens, Rick, Captive Population Dataset Assembly and Tracking,
Analysis, and Modeling, Apple Valley, MN
McClure, Harold M., Yerkes Regional Primate Research Center,
Atlanta, GA
McLaughlin, Ronald M., University of Missouri-Columbia
Institutional Training Award
Mirkovic, Radmila, B-Virus Diagnostic Resource and Research
Laboratory, San Antonio, TX
Mobraaten, Larry E., Cryopreservation of Murine Germplasm, Bar
Harbor, ME
Moore, Pamela B., Diagnostic Research and Clinical Laboratory
Program, New York, NY
Moreland, A. F., University of Florida, Gainesville,
Institutional Training Award
Morin, Phillip A., Genetics Typing Laboratory, Davis, CA
Morse, Stephen S., Diagnostic Research and Clinical Laboratory
Program, New York, NY
Morton, William R., Washington Regional Primate Research Center,
Seattle
Murphy, Frederick A., California Regional Primate Research
Center, Davis, CA
Murphy, James C., Research Animal Diagnostic Laboratory,
Cambridge, MA
Massachusetts Institute of Technology Institutional Training
Award, Cambridge, MA
Osburn, Bennie I., University of California, Davis, Institutional
Training Award
Paigen, Beverly J., Enhancing the Mouse Resource: Recombinant
Inbred Strains, Bar Harbor, ME
Pakes, Steven P., University of Texas Southwestern Medical Center
Institutional Training Award, Dallas
Patterson, Donald F., Referral Center for Animal Models of Human
Genetic Disease, Philadelphia, PA =
Pearson, Stephen L., Specific-Pathogen-Free Macaaque Monkeys,
Alice, TX
Prieur, David J., Washington State University Short-Term
Training: Students in Health Professional Schools, Pullman
Ringler, Daniel H., University of Michigan Institutional Training
Award, Ann Arbor, MI
Rosenthal, Ann, Simian Retrovirus Reference Laboratory, Davis, CA
Rowell, T. Jeffrey, Chimpanzee Breeding and Research Colony, New
Iberia, LA
Scarpelli, Dante G., Registry of Comparative Pathology, Chicago,
IL
Schrier, Judith E., Laboratory Primate Newsletter, Providence, RI
Sharp, John, Transgenic and Targeted Mutant Preservation, Bar
Harbor, ME
Short, Jenny, California Regional Primate Research Center, Davis
Sis, Raymond F., Texas A & M Research Foundation Short-Term
Training: Students in Health Professional Schools, College
Station =
Smith, M. Susan, Oregon Regional Primate Research Center,
Beaverton
Smith, David Glenn, Genetics Typing Laboratory, Davis, CA
Stone, William H., Genetics Typing Laboratory for Chimpanzees,
San Antonio, TX
Genetics Laboratory for Typing Nonhuman Primates, San Antonio, TX
Strandberg, John D., Animal Resource Support for Biomedical
Research, Baltimore, MD
Johns Hopkins University Institutional Training Award, Baltimore,
MD
Swenson, R. Brent, Chimpanzee Breeding and Research Colony,
Atlanta, GA
Taub, David M., Specific-Pathogen-Free Macaques, Yemassee, SC
Tosteson, Daniel C., New England Regional Primate Research
Center, Southborough, MA
Van Hoosier, Gerald L., University of Washington Institutional
Training Award, Seattle
Wagner, Joseph L., Specific-Pathogen-Free Rhesus Monkeys, Miami,
FL
University of Missouri-Columbia Institutional Training Award
Walker, Michael J., Laboratory Primate Newsletter, Providence, RI
Wildes, Martin, B-Virus Diagnostic Resource and Research
Laboratory, San Antonio, TX
Wiley, John D., Wisconsin Regional Primate Center,
Madison
Wolfle, Thomas L., Institute of Laboratory Animal Resources,
Washington, DC
DISCRIMINATION PROHIBITED: Under provisions of applicable public
law enacted by Congress since 1964, no person in the United
States shall, on the grounds of race, color, national origin,
handicap, or age, be excluded from participation in, be denied
the benefits of, or be subjected to discrimination under any
program or activity (or, on the basis of sex, with respect to any
education program or activity) receiving Federal financial
assistance. In addition, Executive Order 11141 prohibits
discrimination on the basis of age by contractors and
subcontractors in the performance of Federal contracts, and
Executive Order 11246 states that no federally funded contract
may discriminate against any employee or applicant for employment
because of race, color, religion, sex, or national origin. =
Resources must be operated in compliance with these laws and
Executive Orders.