University of Wisconsin–Madison

Heather Simmons

Veterinary Pathologist/ Pathology Unit Head

Department

simmons

Animal Services (Pathology), Wisconsin National Primate Research Center

Contact Information

Heather Simmons’ email

(608) 265-8279

Curriculum Vitae

Heather Simmon’s Curriculum Vitae

Aligned research focus

Comparative pathology, aging, cancer, infectious diseases, and neurodegenerative diseases.

Organ system/disease focus

Infectious diaseases, aging, cancer/neoplasia

Research description

My research interests include comparative pathology of nonhuman primates (NHP), wildlife and domestic species; non-human primate models of human disease; and mechanisms of infectious and non-infectious disease. I collaborate with investigators to plan research protocols investigating a variety of research interests including cervical anatomy during pregnancy, spontaneous neoplasia, infectious diseases such as SIV/HIV and listeria, Parkinson’s disease, as well as pathologies associated with diet and aging.

The WNPRC is committed to ensuring maximum scientific use of animals through the Nonhuman Primate Biological Materials Distribution program, which allows distribution of biological samples from animals assigned to short term minimally invasive protocols and animals undergoing terminal procedures.

Selected references

Simmons HA, Age-Associated Pathology in Rhesus Macaques (Macaca mulatta). Veterinary Pathology OnlineFirst, published on February 10, 2016.

Bailey AL, Lauck M, Mohns M, Peterson EJ, Beheler K, Brunner KG, Crosno K, Mejia A, Mutschler J, Gehrke M, Greene J, Ericsen AJ, Weiler A, Lehrer-Brey G, Friedrich TC, Sibley SD, Kallas EG, Capuano S 3rd, Rogers J, Goldberg TL, Simmons HA, O’Connor DH. Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection. Sci Transl Med. 2015 Sep 16;7(305):305ra144.

Joers V, Dilley K, Rahman S, Jones C, Shultz J, Simmons H, Emborg ME. Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates. PLoS One. 2014 Aug 18;9(8):e104850.

Gifford RJ, Nimityongskul FA, Newman LP, Wildeboer S, Lappin PB, Hammond D, Castrovinci P, Piaskowski SM, Reed JS, Beheler KA, Tharmanathan T, Zhang N, Muscat-King S, Rieger M, Fernandes C, Rumpel K, Gardner JP 2nd, Gebhard DH, Janies J, Shoieb A, Pierce BG, Trajkovic D, Rakasz E, Rong S, McCluskie M, Christy C, Merson JR, Jones RB, Nixon DF, Ostrowski MA, Loudon PT, Pruimboom-Brees IM, Sheppard NC. Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic. J Immunol. 2012 Aug 1;189(3):1467-79.

Ohshima-Hosoyama S, Simmons HA, Goecks N, Joers V, Swanson CR, Bondarenko V, Velotta R, Brunner K, Wood LD, Hruban RH, Emborg ME. A monoclonal antibody-GDNF fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys. PLoS One. 2012;7(6):e39036.

Watanabe T, Shinya K, Watanabe S, Imai M, Hatta M, Li C, Wolter BF, Neumann G, Hanson A, Ozawa M, Yamada S, Imai H, Sakabe S, Takano R, Iwatsuki-Horimoto K, Kiso M, Ito M, Fukuyama S, Kawakami E, Gorai T, Simmons HA, Schenkman D, Brunner K, Capuano SV 3rd, Weinfurter JT, Nishio W, Maniwa Y, Igarashi T, Makino A, Travanty EA, Wang J, Kilander A, Dudman SG, Suresh M, Mason RJ, Hungnes O, Friedrich TC, Kawaoka Y. Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques. J Virol. 2011 Dec;85(24):13195-203.