Pathology and Laboratory Medicine
Other Web Pages
Aligned research focus
Organ system/disease focus
HIV/AIDS, Tuberculosis, co-infections
My research lab is interested in understanding the host immune response to HIV and the effect that HIV-infection has on host immunity to other pathogens. HIV+ immunocompromised individuals cannot mount robust immune responses like individuals who are otherwise healthy. We use nonhuman primates with defined host MHC genetics to understand key factors of immunity against SIV, a virus closely related to HIV. In addition, we are using nonhuman primates to better understand the role of host genetics in containment of Mycobacterium tuberculosis (Mtb) and the factors that contribute to latent reactivation of Mtb in macaques co-infected with SIV.
Sutton MS, Burns CM, Weiler AM, Balgeman AJ, Braasch A, Lehrer-Brey G, Friedrich TC, O’Connor SL. Vaccination with Live Attenuated Simian Immunodeficiency Virus (SIV) Protects from Mucosal, but Not Necessarily Intravenous, Challenge with a Minimally Heterologous SIV. Journal of Virology. 2016; 90(12):5541-8.
Weiler AM, Das A, Akinyosoye O, Cui S, O’Connor SL, Scheef EA, Reed JS, Panganiban AT, Sacha JB, Rakasz EG, Friedrich TC, Maness NJ. Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells. Journal of Virology. 2015; 90(4):2119-26.
Gellerup DD, Balgeman AJ, Nelson CW, Ericsen AJ, Scarlotta M, Hughes AL, O’Connor SL. Conditional Immune Escape during Chronic Simian Immunodeficiency Virus Infection. Journal of Virology. 2015; 90(1):545-52.
Adnan S, Colantonio AD, Yu Y, Gillis J, Wong FE, Becker EA, Piatak M Jr, Reeves RK, Lifson JD, O’Connor SL, Johnson RP. CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection. PLoS pathogens. 2015; 11(2):e1004633.
Broman KW, Price DA, Friedrich TC, O’Connor SL. Acute-phase CD8 T cell responses that select for escape variants are needed to control live attenuated simian immunodeficiency virus. Journal of Virology. 2013; 87(16):9353-64.