University of Wisconsin–Madison

Joseph W. Kemnitz

Professor, Department of Cell and Regenerative Biology

Director, Translational Technologies and Resources, Institute for Clinical and Translational Research

Department

Joe Kemnitz

Cell and Regenerative Biology

Contact Information

Curriculum Vitae

Joseph Kemnitz’s Curriculum Vitae

Other web pages

Aligned research focus

Nutrition and aging; reproductive hormones and energy balance; metabolic syndrome

Organ system/disease focus

Age-related pathology, obesity, type 2 diabetes mellitus, endometriosis

Research description

My research career spans more than three decades. Early work focused on the effects of reproductive conditions and gonadal hormones on regulation of energy balance and on the influence of maternal nutrition and metabolism on fetal development. I have also studied obesity and blood glucose regulation. For the past 20-plus years, much of my research has focused on the effects of moderate calorie restriction on the course of aging. Rhesus macaques have been used for most of these studies. As I have taken on administrative roles in the last 15 years, I have coordinated projects in a variety of disciplines and promoted interdisciplinary and translational programs, as well as informatics projects (e.g., Primate Aging Database, Linking Animal Models to Human Disease Initiative and Primate Portal). I am currently involved in the NIH program on clinical and translational science (CTSA program in NIH/NCATS) both locally and nationally and in the Institute of Laboratory Animal Research (ILAR) of the National Academies, particularly in the development of the International Primate Plan to optimize the use and care of nonhuman primates in research.

Selected references

Fowler CG, Chiasson KB, Colman RJ, Kemnitz JW, Beasley TM, Weindruch RH. Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys. Hear Res. 2015. Oct;328:78-86.

Ziegler TE, Kapoor A, Hedman CJ, Binkley N, Kemnitz JW. Measurement of 25-hydroxyvitamin D(2&3) and 1,25-dihydroxyvitamin D(2&3) by tandem mass spectrometry: A primate multispecies comparison. Am J Primatol. 2015. Jul;77(7):801-10. Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 2014. Apr 1;5:3557.

Sridharan A, Bendlin BB, Gallagher CL, Oh JM, Willette AA, Alexander AL, Kemnitz JW, Colman RJ, Weindruch RH, Johnson SC. Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: a fiber tractography study. Neurosci Lett. 2014. May 21;569:38-42.

Hedman CJ, Wiebe DA, Dey S, Plath J, Kemnitz JW, Ziegler TE. Development of a sensitive LC/MS/MS method for vitamin D metabolites: 1,25 Dihydroxyvitamin D2&3 measurement using a novel derivatization agent. J Chromatogr B Analyt Technol Biomed Life Sci. 2014. Mar 15;953-954:62-7.