University of Wisconsin–Madison

Ted Golos, PHD

Professor

Department

Ted Golos

Comparative Biosciences, Obstetrics and Gynecology

Contact Information

Ted Golos’ email

Other web pages

Aligned research focus

The maternal-fetal interface and reproductive tract immunology, embryonic genomic editing

Organ system/disease focus

Recurrent pregnancy loss, female reproductive tract immunology, embryo implantation and placental biology, intrauterine/prenatal programming

Research description

The Golos laboratory examines questions of placental biology relevant to human health and disease, using nonhuman primate models, human clinical materials, and human and nonhuman primate embryonic stem cells in its studies. Study of the maternal-fetal immune dialogue examines nonpolymorphic MHC class I molecules expressed on placental cells and their interactions with the maternal immune system, particularly endometrial natural killer cells and macrophages in promoting pregnancy success, including placental and decidual vascularization. In addition, embryonic stem cells and primate embryos are used to model implantation and placental morphogenesis, with 2-dimensional and 3-dimensional modeling and co-culture systems for understanding how placental cells carry on a dialog with the maternal endometrium. At the interface of these projects is the effect of maternal immune cells directly on rhesus blastocyst function and growth in 3-dimensional co-culture.

Maternal immune recognition of pregnancy and regulation of a healthy implantation site and placenta may play a significant role in pregnancy issues ranging from miscarriage and recurrent pregnancy loss to preeclampsia and intrauterine growth restriction. The primate model will allow direct experimentation at the maternal-fetal interface to develop experimental and therapeutic models of utero-placental function and dysfunction.

Selected references

Rozner AE, Durning M, Kropp J, Wiepz GJ, Golos TG. Macrophages modulate the growth and differentiation of rhesus monkey embryonic trophoblasts. Am J Reprod Immunol. 2016. Sep 17.

Dudley DM, Aliota MT, Mohr EL, Weiler AM, Lehrer-Brey G, Weisgrau KL, Mohns MS, Breitbach ME, Rasheed MN, Newman CM, Gellerup DD, Moncla LH, Post J, Schultz-Darken N, Schotzko ML, Hayes JM, Eudailey JA, Moody MA, Permar SR, O’Connor SL, Rakasz EG, Simmons HA, Capuano S, Golos TG, Osorio JE, Friedrich TC, O’Connor DH. A rhesus macaque model of Asian-lineage Zika virus infection. Nat Commun. 2016. Jun 28;7:12204.

PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune JM, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga K. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nat Immunol. 2015. Apr;16(4):328-34.

Chopra P, Papale LA, White AT, Hatch A, Brown RM, Garthwaite MA, Roseboom PH, Golos TG, Warren ST, Alisch RS. Array-based assay detects genome-wide 5-mC and 5-hmC in the brains of humans, non-human primates, and mice. BMC Genomics. 2014. Feb 13;15:131.

Yoshinaga K, Davies C, White K, Caron K, Golos T, Fazleabas A, Paria B, Mor G, Paul S, Ye X, Dey SK, Spencer T, Roberts RM. Interdisciplinary collaborative team for blastocyst implantation research: inception and perspectives. Am J Reprod Immunol. 2014. Jan;71(1):1-11.

Bondarenko GI, Durning M, Golos TG. Immunomorphological changes in the rhesus monkey endometrium and decidua during the menstrual cycle and early pregnancy. Am J Reprod Immunol. 2012. Oct;68(4):309-21.