Pathobiological Sciences (School of Veterinary Medicine)
WNPRC Virology Services Unit
Other web pages
Aligned research focus
Organ system/disease focus
Why do we get sick? This simple question underpins all research in my laboratory. Our overarching goal is to understand why immune responses sometimes fail to protect us from acute and chronic viral diseases. We study innate and adaptive immune responses to acute and chronic viral infections and the mechanisms viruses have evolved to subvert them. Through our discoveries, we hope to contribute to the global campaigns against pandemic influenza and AIDS.
Our work focuses on immune responses to viral infection in nonhuman primates. Because monkeys’ physiology, genetics and immune systems so closely resemble our own, they provide the best possible approximation of human infections.
Dudley DM, Aliota MT, Mohr EL, Weiler AM, Lehrer-Brey G, Weisgrau KL, Mohns MS, Breitbach ME, Rasheed MN, Newman CM, Gellerup DD, Moncla LH, Post J, Schultz-Darken N, Schotzko ML, Hayes JM, Eudailey JA, Moody MA, Permar SR, O’Connor SL, Rakasz EG, Simmons HA, Capuano S, Golos TG, Osorio JE, Friedrich TC and O’Connor DH. 2016. A rhesus macaque model of Asian-lineage Zika virus infection. Nat Commun. 7:12204.
Moncla LH, Zhong G, Nelson CW, Dinis JM, Mutschler J, Hughes AL, Watanabe T, Kawaoka Y and Friedrich TC. 2016. Selective bottlenecks shape evolutionary pathways taken during mammalian adaptation of a 1918-like avian influenza virus. Cell Host Microbe. 19:169-180.
Florek NW, Weinfurter JT, Jegaskanda S, Brewoo JN, Powell TD, Young GR, Das SC, Hatta M, Broman KW, Hungnes O, Dudman SG, Kawaoka Y, Kent SJ, Stinchcomb DT, Osorio JE and Friedrich TC. 2014. Modified vaccinia virus ankara encoding influenza virus hemagglutinin induces heterosubtypic immunity in macaques. J. Virol. 88:13418-13428.
Jegaskanda S, Weinfurter JT, Friedrich TC and Kent SJ. 2013. Antibody-dependent cellular cytotoxicity (ADCC) is associated with control of pandemic H1N1 influenza virus infection of macaques. J. Virol. 87:5512-5522.
Moncla LH, Ross TM, Dinis JM, Weinfurter JT, Mortimer TD, Schultz-Darken N, Brunner K, Capuano SV, Boettcher C, Post J, Johnson M, Bloom CE, Weiler AM and Friedrich TC. 2013. A novel nonhuman primate model for influenza transmission. PLoS ONE. 8:e78750.
Wilker PR, Dinis JM, Starrett G, Imai M, Hatta M, Nelson CW, O’Connor DH, Hughes AL, Neumann G, Kawaoka Y and Friedrich TC. 2013. Selection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses. Nat Commun. 4:2636.
Weinfurter JT, Brunner K, Capuano III SV, Li C, Broman KW, Kawaoka Y and Friedrich TC. 2011. Cross-Reactive T Cells Are Involved in Rapid Clearance of 2009 Pandemic H1N1 Influenza Virus in Nonhuman Primates. PLoS Pathog. 7:e1002381.