University of Wisconsin–Madison

Nancy Schultz-Darken

Assistant Scientist, Scientific SPI Unit Head

Department

Nancy Schult-Darken, Ph.D.

Wisconsin National Primate Research Center

Contact Information

Nancy Schultz-Darken’s email

(608) 263-3563

Curriculum Vitae

Nancy Schultz-Darken’s Curriculum Vitae

Other web pages

WNPRC Scientific Protocol Implementation Services

Aligned research focus

Provide support in all biomedical research areas. Specific research interests – neuroendocrinology, behavior, and neuroscience.

Research description

My research experience with nonhuman primates includes over 35 years with macaques and over 25 years with marmosets. I also managed both species in WNPRC colonies from 1999-2005.

My scientific experience began with a PhD in animal behavior that was incorporated within a larger department of Pathobiology that included substantial background in physiology, immunology, parasitology, virology, histology, and comparative pathology in addition to the major focus of animal behavior and ecology. Because of this background, I spent most of my scientific career in collaborative studies encompassing teams of experts working together on biomedical research questions. My collaborative work with common marmosets provided me with the opportunity to combine physiology, endocrinology, behavior, and the development of imaging techniques, all of which are areas of interest. Since 2005, my role as scientific head of the Scientific Protocol Implementation unit extended my collaborations into multiple disciplines enabling investigators access to not only the resources at the WNPRC, but the guidance of an investigative scientist. I participate on several grants as co-investigator and as PI on a P01 project with NIMH/NIAID. Many of these projects are part of the Global Infectious disease scientific working group. I am responsible the IACUC protocols on the sub awards and contribute scientifically to all projects. In addition, I oversee the SPI unit in accomplishing research support for all investigators using NHP at the WNPRC, not only my direct collaborators.

As Assistant Scientist at the WNPRC, I participate in research collaborations that emphasize my interests in behavior, neuroendocrinology, and neuroscience such as male parental influences on development, mechanisms of puberty, and social suppression of ovulation. With these interests, I pursue collaborations within the WNPRC scientific working groups of Neuroscience, Reproduction – Regenerative Medicine, and Energy-Metabolism-Chronic Disease. My research emphasis focuses primarily with the common marmoset and currently act as co-investigator on NIH grants related to transgenic marmosets for translational stem cell research and improvements in marmoset nutrition and husbandry.

Selected references

Selected publications related to current involvement with outside research projects:

Dudley DM, Aliota MT, Mohr EL, Weiler AM, Lehrer-Brey G, Weisgrau KL, Mohns MS, Breitbach ME, Rasheed MN, Newman CM, Gellerup DD, Moncla LH, Post J, Schultz-Darken N, Schotzko ML, Hayes JM, Eudailey JA, Moody MA, Permar SR, O’Connor SL, Rakasz EG, Simmons HA, Capuano S, Golos TG, Osorio JE, Friedrich TC, O’Connor DH. A rhesus macaque model of Asian-lineage Zika virus infection. Nature communications. 2016; 7:12204.

Bates JT, Pickens JA, Schuster JE, Johnson M, Tollefson SJ, Williams JV, Davis NL, Johnston RE, Schultz-Darken N, Slaughter JC, Smith-House F, Crowe JE Jr. Immunogenicity and efficacy of alphavirus-derived replicon vaccines for respiratory syncytial virus and human metapneumovirus in nonhuman primates. Vaccine. 2016; 34(7):950-6.

Haase AT, Rakasz E, Schultz-Darken N, Nephew K, Weisgrau KL, Reilly CS, Li Q, Southern PJ, Rothenberger M, Peterson ML, Schlievert PM. Glycerol Monolaurate Microbicide Protection against Repeat. PLoS One. 2015 Jun 9;10(6):e0129465.

Moncla LH, Ross TM, Dinis JM, Weinfurter JT, Mortimer TD, Schultz-Darken N, Brunner K, Capuano SV 3rd, Boettcher C, Post J, Johnson M, Bloom CE, Weiler AM, Friedrich TC. A novel nonhuman primate model for influenza transmission. PLoS One. 2013 Nov 14;8(11):e78750.

Li Q, Estes JD, Schlievert PM, Duan L, Brosnahan AJ, Southern PJ, Reilly CS, Peterson ML, Schultz-Darken N, Brunner KG, Nephew KR, Pambuccian S, Lifson JD, Carlis JV, Haase AT. Glycerol monolaurate prevents mucosal SIV transmission. Nature. 2009. 458:1034-8.

Selected publications related to research interests:

Braun K, Schultz-Darken N, Schneider M, Moore CF, Emborg ME. Development of a novel postnatal neurobehavioral scale for evaluation of common marmoset monkeys. American journal of primatology. 2015; 77(4):401-17.

Schultz-Darken N, Braun K, Emborg, M. Neurobehavioral development of common marmoset monkeys. Dev Psychobiol. 2016 Mar;58(2):141-58. doi: 10.1002/dev.21360. Epub 2015 Oct 26.

Freeman HD, Sullivan J, Hopper LM, Talbot CF, Holmes AN, Schultz-Darken N, Williams LE, Brosnan SF. Different responses to reward comparisons by three primate species. PLoS One. 2013 Oct 9;8(10):e76297.

Schultz-Darken NJ, Pape RM, Tannenbaum PL, Saltzman W, Abbott DH. Lab Anim. 2004 Oct;38(4):393-405. Novel restraint system for neuroendocrine studies of socially living common marmoset monkeys. Lab Anim. 2004 Oct;38(4):393-405.

Ferris CF, Snowdon CT, King JA, Sullivan JM Jr, Ziegler TE, Olson DP, Schultz-Darken NJ, Tannenbaum PL, Ludwig R, Wu Z, Einspanier A, Vaughan JT, Duong TQ. Activation of neural pathways associated with sexual arousal in non-human primates. J Magn Reson Imaging. 2004 Feb;19(2):168-75.