Assistant Professor, Cell and Regenerative Biology, Senior Scientist
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Aligned research focus
Organ system/disease focus
Our research focuses on energy regulation and the impact of caloric restriction on aging in nonhuman primates. Caloric restriction, undernutrition without malnutrition, offers a powerful experimental strategy to explore mechanisms of aging because it is the only intervention that has repeatedly and strongly influenced maximum lifespan and retarded the rate of aging in laboratory rodents. While the beneficial effects of caloric restriction in rodents are well documented, the long-term effects of caloric restriction in primates are still under investigation. Our lab at the Wisconsin National Primate Research Center runs one of only two ongoing, long-term studies of the effects of moderate caloric restriction on aging in rhesus monkeys.
Martin SA, DeMuth TM, Miller KN, Pugh TD, Polewski MA, Colman RJ, Eliceiri KW, Beasley TM, Johnson SC, Anderson RM. Regional and metabolic heterogeneity of the hippocampus is non-uniformly impacted by age and caloric restriction. Aging Cell 15(1):100-110, 2016.
Polewski MA, Burhans MS, Zhao M, Colman RJ, Shanmuganayagam D, Lindstrom MJ, Ntambi JM, Anderson RM. Plasma diacylglycerol composition is a biomarker of metabolic syndrome onset in rhesus monkeys. J Lipid Res 56(8):1461-1470, 2015.
Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 5:3557, 2014. doi:10.1038/ncomms4557.
Ziegler TE, Sosa ME, Peterson LJ, Colman RJ. Using snacks high in fat and protein to improve glucoregulatory function in adolescent male marmosets (Callithrix jacchus). J Am Assoc Lab Anim Sci. 52(6):756-762, 2013.
Colman RJ, Beasley TM, Allison DB, Weindruch R. Skeletal effects of long-term caloric restriction in rhesus monkeys. AGE. 34(5):1133-1143, 2012.
Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 325:201-204, 2009.