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Aligned research focus
Women’s reproductive health, including obesity and type 2 diabetes mellitus (T2DM) within polycystic ovary syndrome (PCOS)
Organ system/disease focus
Polycystic ovary syndrome
I have more than 35 years of experience employing animal models of female reproductive endocrinology to determine pathophysiological mechanisms underlying a variety of reproductive health disorders commonly found in women. More recently, in collaboration with Dr. Daniel Dumesic (UCLA, Obstetrics and Gynecology), my lab developed a comprehensive nonhuman primate model for polycystic ovary syndrome (PCOS) that was the vanguard for a multitude of animal and human studies aimed at determining developmental origins of this most common endocrinopathy in women. We have translated insight gained from the nonhuman primate model to discern pathophysiological mechanisms causing discrete aspects of reproductive and metabolic dysfunction in women with PCOS, including abnormalities at the molecular level. Our work identifies metabolic dysfunction as possibly the initial abnormality in early developmental origins of PCOS.
Dumesic DA, Akopians AL, Madrigal VK, Ramirez E, Margolis DJ, Sarma MK, Thomas AM, Grogan TR, Haykal R, Schooler TA, Okeya BL, Abbott DH, Chazenbalk GD. Hyperandrogenism Accompanies Increased Intra-Abdominal Fat Storage In Normal Weight Polycystic Ovary Syndrome Women. J Clin Endocrinol Metab. 2016. Aug 29.
Abbott DH, Levine JE, Dumesic DA. Translational Insight Into Polycystic Ovary Syndrome (PCOS) From Female Monkeys With PCOS-like Traits. Curr Pharm Des. 2016. Jul 15.
Veiga-Lopez A, Moeller J, Abbott DH, Padmanabhan V. Developmental programming: rescuing disruptions in preovulatory follicle growth and steroidogenesis from prenatal testosterone disruption. J Ovarian Res. 2016. Jun 29;9(1):39.
Smith AL, Freeman SM, Barnhart TE, Abbott DH, Ahlers EO, Kukis DL, Bales KL, Goodman MM, Young LJ. Initial investigation of three selective and potent small molecule oxytocin receptor PET ligands in New World monkeys. Bioorg Med Chem Lett. 2016. Jul 15;26(14):3370-5.
Bird IM, Abbott DH. The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature. J Steroid Biochem Mol Biol. 2016. Oct;163:136-46.
Converse AK, Aubert Y, Allers KA, Sommer B, Abbott DH. Flibanserin-Stimulated Partner Grooming Reflects Brain Metabolism Changes in Female Marmosets. J Sex Med. 2015 Dec;12(12):2256-66.
Kropp J, Roti Roti EC, Ringelstetter A, Khatib H, Abbott DH, Salih SM. Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice. PLoS One. 2015 Nov 6;10(11).